Sarah Teichmann

Sarah Amalia Teichmann (born 1975)[1] FRS FMedSci[18] is head of cellular genetics at the Wellcome Sanger Institute[19] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[20][12] She serves as director of research (equivalent to Professor)[21] in the Cavendish Laboratory,[22] at the University of Cambridge and a senior research fellow at Churchill College, Cambridge.[23][15]

Sarah Teichmann

FRS FMedSci
Sarah Teichmann speaking at the Intelligent Systems for Molecular Biology (ISMB) conference in 2016 in Orlando, Florida
Born
Sarah Amalia Teichmann

(1975-04-15) April 15, 1975[1]
Karlsruhe, Germany
Nationality
  • German
  • American[1]
  • British
EducationEuropean School, Karlsruhe
Alma materUniversity of Cambridge (BA, MA, PhD)
Children2[2][3][4]
Awards
Scientific career
Fields
Institutions
ThesisGenome evolution: analysing proteomes with new methods (1999)
Doctoral advisorCyrus Chothia[12][13]
Doctoral studentsM. Madan Babu[14]
Influences
Websiteteichlab.org

Education

Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.[24] Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia[25] at the Laboratory of Molecular Biology (LMB) on genome evolution.[26]

Career and research

Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London[20] and funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.[27][28]

In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she served as a teaching fellow and director of studies at Trinity College, Cambridge. Since 2016 Teichmann has served as the head of Cellular Genetics at the Wellcome Trust Sanger Institute[19] and a visiting research group leader at the EBI.[12]

Teichmann's research[29][30][31][32] investigates gene expression[33][34][35] and protein complex assembly[36] using both wet laboratory and computational biology techniques.[37] In particular her research group:

...seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.[38]

Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),[39] the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).[24]

As of 2015 Teichmann has supervised several PhD students to completion[40][24] including Madan Babu,[14] Varodom Charoensawa[41] Subhajyoti De[42] Jay Han,[43] Sarah Kay Kummerfeld[44][45] Tina Perica,[46] and Jing Su,[47] and several postdoctoral researchers who have gone on to become Principal investigators (PIs).[24][48][49][50]

Awards and honours

Teichmann has won a number of awards. In 2010, she was awarded the Colworth Medal from the Biochemical Society.[51][52] In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of the European Molecular Biology Organization (EMBO)[7] and the Lister Prize from the Lister Institute of Preventive Medicine.[6] In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society[53] and the EMBO Gold Medal. Teichmann was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads:

Sarah Teichmann is Research Group Leader at EMBL-European Bioinformatics Institute and has made major contributions to biology over the past 15 years. A fundamental discovery was her work to define key biophysical mechanisms in protein complex assembly, showing that protein complexes assemble via distinct, ordered pathways. She showed that these assembly pathways are conserved in evolution and how they may be predicted from 3D structure. Her databases and computational analysis methods have had a broad and deep impact on the community. She represents a new breed of scientists at the interface between computational and experimental molecular biology.[18]

Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.[17] She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research. Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.[10]

In 2020, Teichmann was recognised on The Times 'Science Power List' for her work on the Human Cell Atlas[54] and elected a Fellow of the Royal Society.[55] She won the Suffrage Science award in 2012.[51]

Personal life

Teichmann has two daughters.[2][4] Teichmann is the co-author of the children's language education novel Teenage Detectives,[56] which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.[57]

References
  1. Teichmann, Sarah (2007). "Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV" (PDF). mrc-lmb.cam.ac.uk. Laboratory of Molecular Biology. Archived from the original (PDF) on 2013-02-26.
  2. Greenstreet, Rosanna (2018). "Sarah Teichmann: 'I wake as early as 4am and think about work'". theguardian.com. London: The Guardian.
  3. Marx, Vivien (2014). "The Author File: Janet Thornton". Nature Methods. 11 (2): 115. doi:10.1038/nmeth.2831. PMID 24645189. S2CID 1970327.
  4. Pain, Elisabeth (2015). "Harnessing computer power to understand biology". Science. doi:10.1126/science.caredit.a1500172.
  5. Perica, Tina; Marsh, Joseph A.; Sousa, Filipa L.; Natan, Eviatar; Colwell, Lucy J.; Ahnert, Sebastian E.; Teichmann, Sarah A. (2012). "The emergence of protein complexes: quaternary structure, dynamics and allostery". Biochemical Society Transactions. 40 (3): 475–491. doi:10.1042/BST20120056. PMID 22616857. S2CID 21452774.
  6. "Dr Sarah Teichmann, EMBL-European Bioinformatics Institute & Wellcome Trust Sanger Institute". lister-institute.org.uk. Archived from the original on 2014-10-15.
  7. "Sarah A. Teichmann EBI, Cambridge (Hinxton), United Kingdom EMBO 2012". European Molecular Biology Organization. Archived from the original on 2016-01-19.
  8. "Finding patterns in genes and proteins: decoding the logic of molecular interactions". Royal Society. 2012. Archived from the original on 2012-11-10.
  9. Finding patterns in genes and proteins: decoding the logic of molecular interactions on YouTube, Royal Society
  10. Anon (2017). "ISCB Fellows". iscb.org. International Society for Computational Biology. Archived from the original on 2017-03-20.
  11. Sarah Teichmann publications indexed by Google Scholar
  12. "People & Groups: Sarah Teichmann, Group Leader - Teichmann research group". EMBL-EBI. 2013. Archived from the original on 2013-04-03.
  13. Park, J; Teichmann, S. A.; Hubbard, T; Chothia, C (1997). "Intermediate sequences increase the detection of homology between sequences". Journal of Molecular Biology. 273 (1): 349–54. doi:10.1006/jmbi.1997.1288. PMID 9367767. S2CID 28606158.
  14. Mohan, Madan Babu (2004). Evolution of transcriptional regulatory networks. jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 890159758. EThOS uk.bl.ethos.616113.
  15. Dhillon, Paraminder; Teichmann, Sarah A. (2019). "In conversation with Sarah Teichmann". The FEBS Journal. 286 (8): 1445–1450. doi:10.1111/febs.14806. ISSN 1742-464X. PMID 31012289.
  16. Teichmann, S. A.; Rison, S. C.; Thornton, J. M.; Riley, M; Gough, J; Chothia, C (2001). "The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli". Journal of Molecular Biology. 311 (4): 693–708. CiteSeerX 10.1.1.121.1628. doi:10.1006/jmbi.2001.4912. PMID 11518524.
  17. Gaskell & Kostic (2015). "The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist". Cell. Archived from the original on 2016-04-15. Retrieved 2015-11-25.
  18. Anon (2015). "Dr Sarah Teichmann FMedSci". acmedsci.ac.uk. London: Academy of Medical Sciences. Archived from the original on 2015-07-06.
  19. "Dr Sarah Teichmann, FMedSci, Head of Cellular Genetics". Cambridge: sanger.ac.uk. Archived from the original on 2016-04-15.
  20. Marx, Vivien (2016). "The Author File: Sarah Teichmann". Nature Methods. 13 (4): 279. doi:10.1038/nmeth.3808. ISSN 1548-7091. PMID 27203785. S2CID 205424792.
  21. Anon (2013). "Job titles and duties at the University of Cambridge". University of Cambridge. Archived from the original on 2013-07-03.
  22. Anon (2015). "Dr Sarah Teichmann FMedSci". tcm.phy.cam.ac.uk. Cambridge. Archived from the original on 2015-09-12.
  23. "People – Churchill College". www.chu.cam.ac.uk.
  24. Anon (2015). "Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany". Federation of European Biochemical Societies. Archived from the original on 2015-02-20.
  25. Chothia, C; Gough, J; Vogel, C; Teichmann, S. A. (2003). "Evolution of the protein repertoire". Science. 300 (5626): 1701–3. Bibcode:2003Sci...300.1701C. doi:10.1126/science.1085371. PMID 12805536. S2CID 27681885.
  26. Teichmann, Sarah Amalia (1999). Genome evolution : analysing proteomes with new methods (PhD thesis). University of Cambridge. OCLC 894602472. EThOS uk.bl.ethos.624585.
  27. Babu, M. M.; Luscombe, N. M.; Aravind, L; Gerstein, M; Teichmann, S. A. (2004). "Structure and evolution of transcriptional regulatory networks". Current Opinion in Structural Biology. 14 (3): 283–91. CiteSeerX 10.1.1.471.9692. doi:10.1016/j.sbi.2004.05.004. PMID 15193307.
  28. Luscombe, N. M.; Babu, M. M.; Yu, H; Snyder, M; Teichmann, S. A.; Gerstein, M (2004). "Genomic analysis of regulatory network dynamics reveals large topological changes". Nature. 431 (7006): 308–12. Bibcode:2004Natur.431..308L. doi:10.1038/nature02782. PMID 15372033. S2CID 4391278.
  29. Sarah A. Teichmann author profile page at the ACM Digital Library
  30. Sarah Teichmann at DBLP Bibliography Server
  31. Sarah Teichmann publications indexed by the Scopus bibliographic database. (subscription required)
  32. Sarah Teichmann publications from Europe PubMed Central
  33. Carninci, P; Kasukawa, T; Katayama, S; Gough, J; Frith, M. C.; Maeda, N; Oyama, R; Ravasi, T; Lenhard, B; Wells, C; Kodzius, R; Shimokawa, K; Bajic, V. B.; Brenner, S. E.; Batalov, S; Forrest, A. R.; Zavolan, M; Davis, M. J.; Wilming, L. G.; Aidinis, V; Allen, J. E.; Ambesi-Impiombato, A; Apweiler, R; Aturaliya, R. N.; Bailey, T. L.; Bansal, M; Baxter, L; Beisel, K. W.; Bersano, T; et al. (2005). "The transcriptional landscape of the mammalian genome". Science. 309 (5740): 1559–63. Bibcode:2005Sci...309.1559F. doi:10.1126/science.1112014. PMID 16141072. S2CID 8712839.
  34. Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode:2007Natur.450..203C. doi:10.1038/nature06341. PMID 17994087.
  35. Wilson, D; Charoensawan, V; Kummerfeld, S. K.; Teichmann, S. A. (2008). "DBD--taxonomically broad transcription factor predictions: New content and functionality". Nucleic Acids Research. 36 (Database issue): D88–92. doi:10.1093/nar/gkm964. PMC 2238844. PMID 18073188.
  36. Levy, E. D.; Teichmann, S (2013). "Structural, Evolutionary, and Assembly Principles of Protein Oligomerization". Oligomerization in Health and Disease. Progress in Molecular Biology and Translational Science. 117. pp. 25–51. doi:10.1016/B978-0-12-386931-9.00002-7. ISBN 9780123869319. PMID 23663964.
  37. Perica, T; Kondo, Y; Tiwari, S. P.; McLaughlin, S. H.; Kemplen, K. R.; Zhang, X; Steward, A; Reuter, N; Clarke, J; Teichmann, S. A. (2014). "Evolution of oligomeric state through allosteric pathways that mimic ligand binding". Science. 346 (6216): 1254346. doi:10.1126/science.1254346. PMC 4337988. PMID 25525255.
  38. "Teichmann group Research EMBL-EBI". European Bioinformatics Institute. 2013. Archived from the original on 2013-04-02.
  39. Anon (2015). "UK Government research grants awarded to Sarah Teichmann". Research Councils UK. Archived from the original on 2015-03-03.
  40. Teichmann, Sarah (2015). "Alumni from Sarah Teichmann's Group". European Bioinformatics Institute. Archived from the original on 2015-02-20.
  41. Charoensawan, Varodom (2011). Evolution and dynamics of transcription factors and gene expression patterns. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890150091.
  42. De, Subhajyoti (2008). Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 890154864.
  43. Han, Jay (2007). Structure, function and evolution of protein-protein interactions (PhD thesis). University of Cambridge.
  44. Kummerfeld, Sarah Kay (2006). Towards understanding the protein universe : genome-scale studies of evolution and gene regulation. ethos.bl.uk (PhD thesis). University of Cambridge.
  45. Levy, Emmanuel Doram (2008). Classification, evolution, and assembly of protein complexes. ethos.bl.uk (PhD thesis). University of Cambridge.
  46. Perica, Tina (2013). Evolutionary and structural dynamics of protein complexes (PhD thesis). University of Cambridge. OCLC 890148231.
  47. Su, Jing (2012). Computational prediction of regulatory elements (PhD thesis). University of Cambridge.
  48. Adryan, B; Teichmann, S. A. (2010). "The developmental expression dynamics of Drosophila melanogaster transcription factors". Genome Biology. 11 (4): R40. doi:10.1186/gb-2010-11-4-r40. PMC 2884543. PMID 20384991.
  49. Gsponer, J; Futschik, M. E.; Teichmann, S. A.; Babu, M. M. (2008). "Tight regulation of unstructured proteins: From transcript synthesis to protein degradation". Science. 322 (5906): 1365–8. Bibcode:2008Sci...322.1365G. doi:10.1126/science.1163581. PMC 2803065. PMID 19039133.
  50. Hebenstreit, D; Gu, M; Haider, S; Turner, D. J.; Liò, P; Teichmann, S. A. (2011). "EpiChIP: Gene-by-gene quantification of epigenetic modification levels". Nucleic Acids Research. 39 (5): e27. doi:10.1093/nar/gkq1226. PMC 3061070. PMID 21131282.
  51. Anon (2012). "Honour and heirloom for Sarah Teichmann". Laboratory of Molecular Biology. Archived from the original on 2015-03-03.CS1 maint: date and year (link)
  52. Anon (2015). "Women at Cambridge: Sarah Amalia Teichmann". University of Cambridge. Archived from the original on 2015-02-20.
  53. "Biophysical Society Names 2015 Award Recipients" (PDF). Biophysical Society.
  54. Franklin-Wallis, Oliver (23 May 2020). "From pandemics to cancer: the science power list". The Times. ISSN 0140-0460. Retrieved 2020-05-26.
  55. "Sarah Teichmann". Royal Society. Retrieved 20 September 2020.
  56. Teichmann, Sarah; Teichmann, Virginia (1991). Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities. Germany: Cornelsen Verlag. ISBN 978-3464053362.
  57. Anon. "The Honeycomb: Dr. Virginia Teichmann: Word Lover" (PDF). expat-karlsruhe.com. Retrieved 2015-12-07.
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