SOCS5

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[5][6][7]

SOCS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N34
Identifiers
Aliases	SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs	OMIM: 607094 MGI: 2385459 HomoloGene: 10495 GeneCards: SOCS5
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p21 Start 46,698,952 bp[1] End 46,780,245 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 87,107,679 bp[2] End 87,137,839 bp[2]
Gene ontology Molecular function • epidermal growth factor receptor binding • protein kinase inhibitor activity • receptor tyrosine kinase binding • GO:0001948 protein binding • 1-phosphatidylinositol-3-kinase regulator activity Cellular component • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex Biological process • JAK-STAT cascade • GO:0007243 intracellular signal transduction • epidermal growth factor receptor signaling pathway • negative regulation of epidermal growth factor-activated receptor activity • cell growth • protein ubiquitination • regulation of growth • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of JAK-STAT cascade • negative regulation of T-helper 2 cell differentiation • positive regulation of T-helper 1 cell differentiation • negative regulation of signal transduction • negative regulation of interleukin-6 production • negative regulation of inflammatory response • cellular response to low-density lipoprotein particle stimulus • negative regulation of monocyte chemotactic protein-1 production • vascular endothelial cell response to fluid shear stress • post-translational modification • cytokine-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase activity • phosphatidylinositol phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9655	56468
Ensembl	ENSG00000171150	ENSMUSG00000037104
UniProt	O75159	O54928
RefSeq (mRNA)	NM_144949 NM_014011	NM_019654
RefSeq (protein)	NP_054730 NP_659198	NP_062628
Location (UCSC)	Chr 2: 46.7 – 46.78 Mb	Chr 17: 87.11 – 87.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171150 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037104 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308. S2CID 33269663.
• Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling". Stem Cells. 19 (5): 378–87. doi:10.1634/stemcells.19-5-378. PMID 11553846. S2CID 20847942.
• Ozaki A, Seki Y, Fukushima A, Kubo M (2005). "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model". J. Immunol. 175 (8): 5489–97. doi:10.4049/jimmunol.175.8.5489. PMID 16210657.
• Kario E, Marmor MD, Adamsky K, et al. (2005). "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling". J. Biol. Chem. 280 (8): 7038–48. doi:10.1074/jbc.M408575200. PMID 15590694.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Seki Y, Hayashi K, Matsumoto A, et al. (2002). "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. doi:10.1073/pnas.202477099. PMC 130576. PMID 12242343.
• Magrangeas F, Apiou F, Denis S, et al. (2000). "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 78–81. doi:10.1159/000015490. PMID 10773671. S2CID 19983548.
• Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.