SNX4

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[4][5]

SNX4
Identifiers
AliasesSNX4, ATG24B, sorting nexin 4
External IDsOMIM: 605931 MGI: 1916400 HomoloGene: 36143 GeneCards: SNX4
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q21.2Start125,446,650 bp[1]
End125,520,202 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8723

69150

Ensembl

ENSG00000114520

ENSMUSG00000022808

UniProt

O95219

Q91YJ2

RefSeq (mRNA)

NM_003794

NM_080557

RefSeq (protein)

NP_003785

NP_542124

Location (UCSC)Chr 3: 125.45 – 125.52 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[5]

Interactions

SNX4 has been shown to interact with BIN1.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000114520 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
  5. "Entrez Gene: SNX4 sorting nexin 4".
  6. Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. England. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading



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