RPP38

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.[5][6][7]

RPP38
Identifiers
Aliases	RPP38, ribonuclease P/MRP subunit p38
External IDs	OMIM: 606116 MGI: 2443607 HomoloGene: 4680 GeneCards: RPP38
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 15,097,180 bp[1] End 15,139,818 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 3,328,949 bp[2] End 3,332,643 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrolase activity • GO:0001948 protein binding • ribonuclease P activity Cellular component • cell nucleus • nucleolus • nucleoplasm • nucleolar ribonuclease P complex • fibrillar center Biological process • RNA phosphodiester bond hydrolysis, endonucleolytic • RNA phosphodiester bond hydrolysis • tRNA processing • tRNA 5'-leader removal Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10557	227522
Ensembl	ENSG00000152464	ENSMUSG00000049950
UniProt	P78345 Q5VUC3	A2AJG0
RefSeq (mRNA)	NM_001097590 NM_001265601 NM_006414 NM_183005	NM_001013376
RefSeq (protein)	NP_001091059 NP_001252530 NP_006405 NP_892117	NP_001013394
Location (UCSC)	Chr 10: 15.1 – 15.14 Mb	Chr 2: 3.33 – 3.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RPP38 has been shown to interact with POP4.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000152464 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049950 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eder PS, Kekuda R, Stolc V, Altman S (March 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc. Natl. Acad. Sci. U.S.A. 94 (4): 1101–6. doi:10.1073/pnas.94.4.1101. PMC 19751. PMID 9037013.
6. Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S (June 1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC 1369627. PMID 9630247.
7. "Entrez Gene: RPP38 ribonuclease P/MRP 38kDa subunit".
8. Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jarrous N, Wolenski JS, Wesolowski D, Lee C, Altman S (1999). "Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P". J. Cell Biol. 146 (3): 559–72. doi:10.1083/jcb.146.3.559. PMC 2150555. PMID 10444065.
• Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.