POP4 (gene)

Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene.[5][6][7]

POP4
Identifiers
Aliases	POP4, RPP29, POP4 homolog, ribonuclease P/MRP subunit
External IDs	OMIM: 606114 MGI: 1913411 HomoloGene: 31392 GeneCards: POP4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q12 Start 29,606,283 bp[1] End 29,617,237 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 38,261,996 bp[2] End 38,271,423 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribonuclease activity • GO:0001948 protein binding • ribonuclease P RNA binding • ribonuclease MRP activity • hydrolase activity • RNA binding • ribonuclease P activity Cellular component • ribonuclease P complex • nucleolus • cell nucleus • nucleoplasm • multimeric ribonuclease P complex • ribonuclease MRP complex Biological process • tRNA processing • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA 5'-leader removal • rRNA processing • RNA processing • RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10775	66161
Ensembl	ENSG00000105171	ENSMUSG00000030423
UniProt	O95707	Q9CR08
RefSeq (mRNA)	NM_006627	NM_025390
RefSeq (protein)	NP_006618	NP_079666
Location (UCSC)	Chr 19: 29.61 – 29.62 Mb	Chr 7: 38.26 – 38.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POP4 (gene) has been shown to interact with RPP38[8] and POP1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000105171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030423 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Eenennaam H, Pruijn GJ, van Venrooij WJ (Jul 1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC 148449. PMID 10352175.
6. Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–7. doi:10.1017/S135583829800185X. PMC 1369747. PMID 10024167.
7. "Entrez Gene: POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)".
8. Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
• Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153. PMID 11455963.