Prosolanapyrone-III cycloisomerase
Prosolanapyrone-III cycloisomerase (EC 5.5.1.20, Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)) is an enzyme with systematic name prosolanapyrone-III:(-)-solanapyrone A isomerase.[1][2][3] This enzyme catalyses the following chemical reaction
- prosolanapyrone III (-)-solanapyrone A
| Prosolanapyrone-III cycloisomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.5.1.20 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi.
References
- Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I (June 2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani". ChemBioChem. 11 (9): 1245–52. doi:10.1002/cbic.201000173. PMID 20486243.
- Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A (May 1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1384 (2): 387–95. doi:10.1016/s0167-4838(98)00040-5. PMID 9659400.
- Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H (February 2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani". Bioscience, Biotechnology, and Biochemistry. 72 (2): 604–7. doi:10.1271/bbb.70600. PMID 18256508.
External links
- Prosolanapyrone-III+cycloisomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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