Precorrin-6Y C5,15-methyltransferase (decarboxylating)
In enzymology, a precorrin-6Y C5,15-methyltransferase (decarboxylating) (EC 2.1.1.132) is an enzyme that catalyzes the chemical reaction
- 2 S-adenosyl-L-methionine + precorrin-6Y 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2
The conversion of precorrin-6B to precorrin-8 is catalysed by the enzyme CobL in Pseudomonas denitrificans
| precorrin-6Y C5,15-methyltransferase (decarboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.132 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme are S-adenosyl methionine and precorrin 6Y; its three products are S-adenosylhomocysteine, precorrin 8X, and CO2.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating). Other names in common use include precorrin-6 methyltransferase, precorrin-6Y methylase and CobL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.
See also
References
- Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J (1992). "Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product". J. Bacteriol. 174 (3): 1050–2. PMC 206191. PMID 1732195.
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