Peter Colman

Education

Colman was educated at the University of Adelaide, where he received a Bachelor of Science degree in physics in 1966[1] and a PhD in 1969 for research on the chemical structure of parabanic acid complexes supervised by Harry Medlin.[6]

Research and career

Colman's research interests are in structural biology,[7][10][11] especially of human B-cell lymphoma 2 (BCL-2).[12][13][14][15] Colman determined the three-dimensional structure of the influenza virus neuraminidase and, in one of the earliest cases of structure-based drug design, discovered zanamivir, the first-in-class neuraminidase inhibitor for influenza.[16] His subsequent structural studies on resistance to this drug class suggested how to design drugs against moving targets.[16] His discoveries underpin drug stockpiling for pandemic preparedness.[16] He has made seminal contributions to structural studies of antibodies and antibody-antigen complexes.[16] Recent work on apoptosis solves the long-standing problem of how pro-apoptotic Bax changes conformation to dimerise and then oligomerise and permeabilise the mitochondrial membrane, an essential step in the intrinsic cell-death pathway.[16]

His work has been published in leading peer reviewed scientific journals including Nature,[7][17][18][19][20][21] the Journal of Molecular Biology,[22] and Nature Reviews Molecular Cell Biology.[23]

Awards and honours
Peter Colman, showing his flu protein (neuraminidase) model to Frank Macfarlane Burnet in 2001.

In the Queen's 2017 Birthday Honours Colman was appointed a Companion of the Order of Australia (AC), Australia's highest civilian honour, "for eminent service to medical research, particularly in the fields of structural biology and medicinal chemistry, as a leader in the commercial translation of scientific discoveries, to professional organisations, and as a mentor of young scientists".[24]

Colman was elected a Fellow of the Royal Society (FRS) in 2014.[16] In 2001 he was awarded a Centenary Medal "For service to Australian society and science in structural biology".[5] Colman was also elected a Fellow of the Australian Academy of Science in 1989 and a Fellow of the Australian Academy of Technological Sciences and Engineering in 1997.[1] He was awarded the Macfarlane Burnet Medal and Lecture in 1995.[25]

References
  1. Anon (2014). "Colman, Dr Peter Malcolm". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U23546. (subscription or UK public library membership required) (subscription required)
  2. Peter Malcolm Colman, CSIROpedia, Commonwealth Scientific and Industrial Research Organisation
  3. Colman, P. M. (1994). "Influenza virus neuraminidase: Structure, antibodies, and inhibitors". Protein Science. 3 (10): 1687–96. doi:10.1002/pro.5560031007. PMC 2142611. PMID 7849585.
  4. "Professor Peter Colman". aips.net. Australian Institute of Policy and Science.
  5. COLMAN, Peter Malcolm - Centenary Medal, 1 January 2001, It's an Honour.
  6. Colman, Peter Malcolm (1969). The physical structure of two parabanic acid complexes and an investigation of short intermolecular carbon-oxygen contacts. trove.nla.gov.au (PhD thesis). University of Adelaide. hdl:2440/19998. OCLC 222734513.
  7. Huber, R.; Deisenhofer, J.; Colman, P. M.; Matsushima, M.; Palm, W. (1976). "Crystallographic structure studies of an IgG molecule and an Fc fragment". Nature. 264 (5585): 415–20. Bibcode:1976Natur.264..415H. doi:10.1038/264415a0. PMID 1004567.
  8. Colman, P. M.; Freeman, H. C.; Guss, J. M.; Murata, M.; Norris, V. A.; Ramshaw, J. A. M.; Venkatappa, M. P. (1978). "X-ray crystal structure analysis of plastocyanin at 2.7 Å resolution". Nature. 272 (5651): 319. Bibcode:1978Natur.272..319C. doi:10.1038/272319a0.
  9. Peter Colman publications indexed by the Scopus bibliographic database. (subscription required)
  10. Colman, P. M. (1994). "Effects of amino acid sequence changes on antibody-antigen interactions". Research in Immunology. 145 (1): 33–6. doi:10.1016/S0923-2494(94)80039-1. PMID 7516563.
  11. Type 1 Diabetes Research Update – with Professor Peter Colman on YouTube
  12. Lessene, G.; Czabotar, P. E.; Colman, P. M. (2008). "BCL-2 family antagonists for cancer therapy". Nature Reviews Drug Discovery. 7 (12): 989–1000. doi:10.1038/nrd2658. PMID 19043450.
  13. Brady, R. M.; Vom, A.; Roy, M. J.; Toovey, N.; Smith, B. J.; Moss, R. M.; Hatzis, E.; Huang, D. C. S.; Parisot, J. P.; Yang, H.; Street, I. P.; Colman, P. M.; Czabotar, P. E.; Baell, J. B.; Lessene, G. (2014). "De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization". Journal of Medicinal Chemistry. 57 (4): 1323–43. doi:10.1021/jm401948b. PMID 24456288.
  14. Koehler, M. F. T.; Bergeron, P.; Choo, E. F.; Lau, K.; Ndubaku, C.; Dudley, D.; Gibbons, P.; Sleebs, B. E.; Rye, C. S.; Nikolakopoulos, G.; Bui, C.; Kulasegaram, S.; Kersten, W. J. A.; Smith, B. J.; Czabotar, P. E.; Colman, P. M.; Huang, D. C. S.; Baell, J. B.; Watson, K. G.; Hasvold, L.; Tao, Z. F.; Wang, L.; Souers, A. J.; Elmore, S. W.; Flygare, J. A.; Fairbrother, W. J.; Lessene, G. (2014). "Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL". ACS Medicinal Chemistry Letters. 5 (6): 662–7. doi:10.1021/ml500030p. PMC 4060937. PMID 24944740.
  15. Chen, L.; Willis, S. N.; Wei, A.; Smith, B. J.; Fletcher, J. I.; Hinds, M. G.; Colman, P. M.; Day, C. L.; Adams, J. M.; Huang, D. C. S. (2005). "Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function". Molecular Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
  16. Anon (2014). "Professor Peter Colman FRS". royalsociety.org. London: Royal Society. Archived from the original on 5 May 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  17. von Itzstein, M.; Wu, W. Y.; Kok, G. B.; Pegg, M. S.; Dyason, J. C.; Jin, B.; Phan, T. V.; Smythe, M. L.; White, H. F.; Oliver, S. W.; Colman, P. M.; Varghese, J. N.; Ryan, D. M.; Woods, J. M.; Bethell, R. C.; Hotham, V. J.; Cameron, J. M.; Penn, C. R. (1993). "Rational design of potent sialidase-based inhibitors of influenza virus replication". Nature. 363 (6428): 418–23. Bibcode:1993Natur.363..418V. doi:10.1038/363418a0. PMID 8502295.
  18. Chothia, C.; Lesk, A. M.; Tramontano, A.; Levitt, M.; Smith-Gill, S. J.; Air, G.; Sheriff, S.; Padlan, E. A.; Davies, D.; Tulip, W. R.; Colman, P. M.; Spinelli, S.; Alzari, P. M.; Poljak, R. J. (1989). "Conformations of immunoglobulin hypervariable regions". Nature. 342 (6252): 877–883. Bibcode:1989Natur.342..877C. doi:10.1038/342877a0. PMID 2687698.
  19. Varghese, J. N.; Laver, W. G.; Colman, P. M. (1983). "Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution". Nature. 303 (5912): 35–40. doi:10.1038/303035a0. PMID 6843658.
  20. Colman, P. M.; Laver, W. G.; Varghese, J. N.; Baker, A. T.; Tulloch, P. A.; Air, G. M.; Webster, R. G. (1987). "Three-dimensional structure of a complex of antibody with influenza virus neuraminidase". Nature. 326 (6111): 358–63. doi:10.1038/326358a0. PMID 2436051.
  21. Colman, P. M.; Varghese, J. N.; Laver, W. G. (1983). "Structure of the catalytic and antigenic sites in influenza virus neuraminidase". Nature. 303 (5912): 41–4. doi:10.1038/303041a0. PMID 6188957.
  22. Lawrence, M. C.; Colman, P. M. (1993). "Shape Complementarity at Protein/Protein Interfaces". Journal of Molecular Biology. 234 (4): 946–50. doi:10.1006/jmbi.1993.1648. PMID 8263940.
  23. Colman, P. M.; Lawrence, M. C. (2003). "The structural biology of type I viral membrane fusion". Nature Reviews Molecular Cell Biology. 4 (4): 309–19. doi:10.1038/nrm1076. PMID 12671653.
  24. Companion (AC) in the General Division of the Order of Australia Archived 22 March 2018 at the Wayback Machine, Media Notes, Queen's Birthday 2017, www.gg.gov.au
  25. "Macfarlane Burnet Medal and Lecture". Australian Academy of Science. Retrieved 22 February 2017.

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