PIGV

GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene.[4][5]

PIGV
Identifiers
Aliases	PIGV, GPI-MT-II, HPMRS1, PIG-V, phosphatidylinositol glycan anchor biosynthesis class V
External IDs	OMIM: 610274 MGI: 2442480 HomoloGene: 5354 GeneCards: PIGV
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,787,472 bp[1] End 26,798,398 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mannosyltransferase activity • transferase activity, transferring glycosyl groups • transferase activity • glycolipid mannosyltransferase activity Cellular component • membrane • mannosyltransferase complex • endoplasmic reticulum • integral component of membrane • endoplasmic reticulum membrane Biological process • GPI anchor biosynthetic process • preassembly of GPI anchor in ER membrane • mannosylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55650	230801
Ensembl	ENSG00000060642	ENSMUSG00000043257
UniProt	Q9NUD9	Q7TPN3
RefSeq (mRNA)	NM_017837 NM_001202554	NM_001145955 NM_001145956 NM_178698 NM_001356466
RefSeq (protein)	NP_001189483 NP_060307 NP_001361407 NP_001361409 NP_001361410 NP_001361411 NP_001361412 NP_001361413 NP_001361414 NP_001361415	NP_001139427 NP_001139428 NP_848813 NP_001343395
Location (UCSC)	Chr 1: 26.79 – 26.8 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Hyperphosphatasia with mental retardation syndrome (HPMRS)

References

1. GRCh38: Ensembl release 89: ENSG00000060642 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T (Mar 2005). "PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol". J Biol Chem. 280 (10): 9489–97. doi:10.1074/jbc.M413867200. PMID 15623507.
5. "Entrez Gene: PIGV phosphatidylinositol glycan anchor biosynthesis, class V".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Fabre AL, Orlean P, Taron CH (2005). "Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly". FEBS J. 272 (5): 1160–8. doi:10.1111/j.1742-4658.2005.04551.x. PMID 15720390. S2CID 25106178.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.