Orthobunyavirus

Orthobunyavirus is a genus of the Peribunyaviridae family[2] in the order Bunyavirales. There are currently ~170 viruses recognised in this genus. These have been assembled into 97 species[1] and 20 serogroups.

Orthobunyavirus
Orthobunyavirus structure (left); transmission electron micrograph of California encephalitis virus (right)
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Peribunyaviridae
Genus: Orthobunyavirus
Type species
Bunyamwera orthobunyavirus
Species[1]

see text

The name Orthobunyavirus derives from Bunyamwera, Uganda,[3] where the original type species Bunyamwera orthobunyavirus was first discovered,[4] along with the prefix orthos (ορϑοϛ) meaning 'straight.'[5]

The type species is Bunyamwera orthobunyavirus.

Epidemiology

The genus is most diverse in Africa, Australia and Oceania, but occurs almost worldwide. Most orthobunyavirus species are transmitted by gnats and cause diseases of cattle. The California encephalitis virus, the La Crosse virus and the Jamestown Canyon virus are North American species that cause encephalitis in humans.

Virology
Genome of Bunyamwera virus of the genus Orthosbunyavirus[3]
  • The type species is Bunyamwera orthobunyavirus.[6]
  • The virus is spherical, diameter 80 nm to 120 nm, and comprises three negative-sense single stranded RNA molecules encapsulated in a ribonucleocapsid.[7]
  • The three RNAs are described as S, M and L (for Small, Medium and Large) and are circa 1kb (kilobases), 4.5kb and 6.9kb in length[8][7][9]
  • The S RNA encodes the Nucleocapsid protein (N protein) and a non structural protein (NS Protein).[10]
  • The M RNA encodes a polyprotein which is cleaved by host protease into Gn, NSm and Gc proteins.[7]
  • The L RNA encodes the viral RNA dependent RNA Polymerase or L Protein[11]

Life cycle

Vectors

The primary vectors of Orthobunyaviruses are hematophagous insects of the Culicidae family, including members from a number of mosquito genera (including Aedes, Coquillettidia, Culex, Culiseta, and Anopheles) and biting midges (such as Culicoides paraensis).[12][9] Although transmission by ticks and bed bugs may also occur. Viral vector preference is generally strict, with only a one or very small number of vectors transmitting a specific virus in the region, even where multiple viruses and vectors overlap.[13] Organisms related to the preferential vector may be able to carry a virus but not competently transmit it.[9]

The vector arthropod acquires the virus while taking a blood meal from an infected host. In mosquitoes, replication of orthobunyaviruses is enhanced by immune modulation that occurs as a result of blood protein digestion producing GABA and the activation of GABAergic signalling.[14] Infection is transmitted to a new host via viral particles in vector saliva.[14] Orthobunyavirus infection in arthropod cells is not fully understood, but is generally non-cytopathological and deleterious effects are minimal.[15][13] Infected mosquitoes may experience an increase in fitness.[13] Transorvarial transmission has been observed among mosquitoes infected with orthobunyaviruses of the California serogroup[9] Like mosquitoes, only female culicoid midges feed on blood; they prefer indoor feeding particularly during rain.[9]

Sylvatic Cycle Hosts

In the slyvatic cycle, viruses are transmitted between mammalian hosts by the arthropod vector. A diverse range of mammals have been identified or implicated as hosts or reservoirs of orthobunyaviruses including: non-human primates, sloths, wild and domestic birds, marmosets, rodents, and large mammals such as deer, moose, and elk.[12][9]

Infection

Infection begins with the bite of an infected competent vector organism. Viral entry proceeds by receptor-mediated (clathrin-dependent) endocytosis, but which receptors unknown.[15] Although, Heparan sulfate and DC-SIGN (CD209 or Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin) have been identified as viral entry components in some orthobunyaviruses.[13][15] Gn/Gc heterodimers on the viral surface are responsible for target cell recognition,[16] with Gc is considered the primary attachment protein, although Gn has been suggested as the attachment protein for LACV in arthropod cells.[13] Acidification of the endosome triggers a conformational change in the Gc fusion peptide, uncoating the ribonuclearprotein (RNP) as it is released into the cytoplasm.[16]

Upon release into the cytoplasm, primary transcription begins with an endonuclease domain on L protein engaging in a process known as "cap-snatching."[13][16] During cap-snatching, 10-18 nucleotides of 5' 7-methylguanylate primers are cleaved from host mRNAs and attached to prime the 5' end of the viral RNAs.[9] Like all negative-sense RNA viruses, orthobunyaviruses require ongoing, concurrent translation by the host cell to produce full-length viral mRNAs, consequently the 3' end of orthobunyavirus mRNAs lack polyadenylation.[9] Notably they are also missing the signal for polyadenylation; instead the 3' ends are thought to form a stem-loop structure.[9][13] Antigenomes (full length positive-sense RNAs) used as templates for replication of the viral genome are produced by L protein RdRp without the need for primers.[9] Both negative-sense genomes and positive-sense antigenomes are associated with N proteins (forming RNPs) at all times during the replication cycle.[17] Thus, N and L are the minimum proteins required for transcription and replication[16][13]

The M genome segment codes for the Gn-NSm-Gc polyprotein on a single open-reading frame (ORF) which is cotranslationally cleaved by internal signal peptides and host signal peptidase.[16][9] The free glycoproteins Gc and Gn insert into the membrane of the endoplasmic reticulum and form heterodimers. A Golgi retention signal on Gn, permits transport of the heterodimers to the Golgi apparatus, where glycosylation occurs. The presence of the viral glycoproteins modifies the Golgi membrane to enable budding of RNPs into a Golgi derived tubular viral factory (viroplasm).[15][9] As segmented viruses, orthobuynaviruses require precise packaging of one of each of the three genomic segments into the final virion to produce a mature, infectious particle. Packaging appears to be directed by signals contained entirely within UTR sequences.[13] The packaged genomes acquire a lipid membrane as they bud into the viral factories, are then transported to the host cell plasma membrane and released via exocytosis. A final gylcoprotein modification upon release produces a mature, infectious particle.[13]

Evolution

Orthobunyaviruses evolve partly by a key mechanism known as genomic reassortment, which also occurs in other segmented viruses. When viruses of the same group co-infect a host cell, mixtures and novel combinations of the S, M, and L segments can be produced, increasing diversity. The most common reassortment events are with the L and S segments.[18]

Taxonomy

Species

The taxonomy remains somewhat fluid as relatively few viral genomes in this genus have been sequenced. Several of the viruses listed have been shown to be recombinants of other viruses and may be reclassified. There are 88 species in the genus:[1]

  • Acara orthobunyavirus
  • Aino orthobunyavirus
  • Akabane orthobunyavirus
  • Alajuela orthobunyavirus
  • Anadyr orthobunyavirus
  • Anhembi orthobunyavirus
  • Anopheles A orthobunyavirus
  • Anopheles B orthobunyavirus
  • Bakau orthobunyavirus
  • Batai orthobunyavirus
  • Batama orthobunyavirus
  • Bellavista orthobunyavirus
  • Benevides orthobunyavirus
  • Bertioga orthobunyavirus
  • Bimiti orthobunyavirus
  • Birao orthobunyavirus
  • Botambi orthobunyavirus
  • Bozo orthobunyavirus
  • Bunyamwera orthobunyavirus
  • Bushbush orthobunyavirus
  • Buttonwillow orthobunyavirus
  • Bwamba orthobunyavirus
  • Cache Valley orthobunyavirus
  • Cachoeira Porteira orthobunyavirus
  • California encephalitis orthobunyavirus
  • Capim orthobunyavirus
  • Caraparu orthobunyavirus
  • Cat Que orthobunyavirus
  • Catu orthobunyavirus
  • Enseada orthobunyavirus
  • Faceys paddock orthobunyavirus
  • Fort Sherman orthobunyavirus
  • Gamboa orthobunyavirus
  • Guajara orthobunyavirus
  • Guama orthobunyavirus
  • Guaroa orthobunyavirus
  • Iaco orthobunyavirus
  • Ilesha orthobunyavirus
  • Ingwavuma orthobunyavirus
  • Jamestown Canyon orthobunyavirus
  • Jatobal orthobunyavirus
  • Kaeng Khoi orthobunyavirus
  • Kairi orthobunyavirus
  • Keystone orthobunyavirus
  • Koongol orthobunyavirus
  • La Crosse orthobunyavirus
  • Leanyer orthobunyavirus
  • Lumbo orthbunyavirus
  • Macaua orthobunyavirus
  • Madrid orthobunyavirus
  • Maguari orthobunyavirus
  • Main Drain orthobunyavirus
  • Manzanilla orthobunyavirus
  • Marituba orthobunyavirus
  • Melao orthobunyavirus
  • Mermet orthobunyavirus
  • Minatitlan orthobunyavirus
  • MPoko orthobunyavirus
  • Nyando orthobunyavirus
  • Olifantsvlei orthobunyavirus
  • Oriboca orthobunyavirus
  • Oropouche orthobunyavirus
  • Patois orthobunyavirus
  • Peaton orthobunyavirus
  • Potosi orthobunyavirus
  • Sabo orthobunyavirus
  • San Angelo orthobunyavirus
  • Sango orthobunyavirus
  • Schmallenberg orthobunyavirus
  • Serra do Navio orthobunyavirus
  • Shuni orthobunyavirus
  • Simbu orthobunyavirus
  • Snowshoe hare orthobunyavirus
  • Sororoca orthobunyavirus
  • Tacaiuma orthobunyavirus
  • Tahyna orthobunyavirus
  • Tataguine orthobunyavirus
  • Tensaw orthobunyavirus
  • Tete orthobunyavirus
  • Thimiri orthobunyavirus
  • Timboteua orthobunyavirus
  • Trivittatus orthobunyavirus
  • Turlock orthobunyavirus
  • Utinga orthobunyavirus
  • Witwatersrand orthobunyavirus
  • Wolkberg orthobunyavirus
  • Wyeomyia orthobunyavirus
  • Zegla orthobunyavirus

Organized by serogroups

Eighteen serogroups have been recognized on the basis of the results of cross-hemagglutination inhibition and antibody neutralization relationships. Another - Wyeomyia - has since been recognised. Several viruses have not yet been classified into one of the serogroups. The Simbu serogroup is the largest and contains at least 25 members. There are at least 13 members in the Group C serogroup. Medically important viruses belong to the Bwamba, Bunyamwera, California, Group C and Simbu serogroups.

List of species and strains of orthobnyavirus by serogroup


Viruses by serogroup:

Anopheles A serogroup

  • Anopheles A virus
  • Tacaiuma virus
  • Virgin River virus
  • Trombetas complex
    • Arumateua virus
    • Caraipé virus
    • Trombetas virus
    • Tucuruí virus

Anopheles B serogroup

  • Anopheles B virus
  • Boraceia virus

Bakau serogroup

  • Bakau virus
  • Nola virus

Bunyamwera serogroup

  • Ngari complex
    • Garissa virus
    • KV-141 virus
    • Ngari virus

Bwamba serogroup

California serogroup

Capim serogroup

Gamboa serogroup

Group C serogroup

  • Bruconha virus
  • Ossa virus
  • Caraparu complex
    • Apeu virus
    • Bruconha virus
    • Caraparu virus
    • Vinces virus
  • Madrid complex
    • Madrid virus
    • Marituba complex
    • Gumbo limbo virus
    • Marituba virus
    • Murutucu virus
    • Nepuyo virus
    • Restan virus
  • Oriboca complex
    • Itaqui virus
    • Oriboca virus

Guama serogroup

  • Ananindeua virus
  • Bertioga virus
  • Bimiti virus
  • Cananeia virus
  • Catu virus
  • Gan Gan virus
  • Guama virus
  • Guaratuba virus
  • Itimirim virus
  • Mahogany hammock virus
  • Mirim virus
  • Timboteua virus
  • Trubanaman virus

Koongol serogroup

  • Koongol virus
  • Wongal virus

Mapputta serogroup

  • Buffalo Creek virus
  • Mapputta virus
  • Maprik virus
  • Murrumbidgee virus
  • Salt Ash virus

Minatitlan serogroup

  • Minatitlan virus
  • Palestina virus

Nyando serogroup

  • Eretmapodites virus
  • Nyamdo virus

Olifanstlei serogroup

  • Botambi virus
  • Olifanstlei virus

Patois serogroup

  • Abras virus
  • Babahoyo virus
  • Pahayokee virus
  • Patois virus
  • Shark River virus
  • Zegla virus

Simbu serogroup

  • Iquitos virus
  • Jatobal virus
  • Leanyer virus
  • Mermet virus
  • Oya virus
  • Thimiri virus
  • Sathuperi serocomplex
    • Douglas virus
    • Sathuperi virus
  • Shamonda serocomplex
    • Peaton virus
    • Shamonda virus
  • Shuni serocomplex
    • Aino virus
    • Shuni virus

Tete serogroup

  • Bahig virus
  • Batama virus
  • Matruh virus
  • Tete virus
  • Tsuruse virus
  • Weldona virus

Turlock serogroup

  • Kedah virus
  • Lednice virus
  • M'Poko virus
  • Turlock virus
  • Umbre virus

Wyeomyia serogroup

  • Anhembi virus
  • Cachoeira Porteira virus
  • Iaco virus
  • Macaua virus
  • Sororoca virus
  • Taiassui virus
  • Tucunduba virus
  • Wyeomyia virus

Unclassified

  • Batama virus
  • Bellavista virus
  • Belmont virus
  • Enseada virus
  • Estero Real virus
  • Herbert virus
  • Jonchet virus
  • Jurona virus
  • Kaeng Khei virus
  • Kibale virus
  • Kowanyama virus
  • Mojuí dos Campos virus
  • Ntwetwe virus[20]
  • Taï virus
  • Tataguine virus
  • Triniti virus
  • Witwatersrand virus
  • Wolkberg virus
  • Yacaaba virus

References
  1. "Virus Taxonomy: 2019 Release". talk.ictvonline.org. International Committee on Taxonomy of Viruses. Retrieved 6 May 2020.
  2. Hughes, HR; Adkins, S; Alkhovskiy, S; Beer, M; Blair, C; Calisher, CH; Drebot, M; Lambert, AJ; de Souza, WM; Marklewitz, M; Nunes, MRT; Shí 石晓宏, X; ICTV Report Consortium (January 2020). "ICTV Virus Taxonomy Profile: Peribunyaviridae". The Journal of General Virology. 101 (1): 1–2. doi:10.1099/jgv.0.001365. PMC 7414433. PMID 31846417.
  3. "ICTV Report Peribunyaviridae".
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  5. Griffith C (2005). "Dictionary of Botanical Epithets". Dictionary of Botanical Epithets. Retrieved 31 January 2019. orthos orth adj ορϑοϛ straight
  6. "International Committee on Taxonomy of Viruses, Bunyaviridae". bio-mirror.cn. Archived from the original on 9 September 2013. Retrieved 20 December 2018.
  7. "ViralZone page". viralzone.expasy.org. Retrieved 20 December 2018.
  8. Kascsak RJ, Lyons MJ (October 1977). "Bunyamwera virus. I. The molecular complexity of the virion RNA". Virology. 82 (1): 37–47. doi:10.1016/0042-6822(77)90030-7. PMID 898678.
  9. Evans AB, Peterson KE (August 2019). "Throw out the Map: Neuropathogenesis of the Globally Expanding California Serogroup of Orthobunyaviruses". Viruses. 11 (9): 794. doi:10.3390/v11090794. PMC 6784171. PMID 31470541.
  10. Genbank: Bunyamwera virus segment S, complete sequence
  11. Genbank: Bunyamwera virus L segment, complete sequence
  12. Sakkas H, Bozidis P, Franks A, Papadopoulou C (April 2018). "Oropouche Fever: A Review". Viruses. 10 (4): 175. doi:10.3390/v10040175. PMC 5923469. PMID 29617280.
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  16. Pawaiya RV, Gupta VK (2013-11-21). "A review on Schmallenberg virus infection: a newly emerging disease of cattle, sheep and goats". Veterinární Medicína. 58 (10): 516–526. doi:10.17221/7083-vetmed. ISSN 0375-8427.
  17. Zheng W, Tao YJ (May 2013). "Genome encapsidation by orthobunyavirus nucleoproteins". Proceedings of the National Academy of Sciences of the United States of America. 110 (22): 8769–70. Bibcode:2013PNAS..110.8769Z. doi:10.1073/pnas.1306838110. PMC 3670359. PMID 23696659.
  18. da Rosa, Jorge Fernando Travassos; de Souza, William Marciel; de Paula Pinheiro, Francisco; Figueiredo, Mário Luiz; Cardoso, Jedson Ferreira; Acrani, Gustavo Olszanski; Nunes, Márcio Roberto Teixeira (2017-02-06). "Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus". The American Journal of Tropical Medicine and Hygiene. 96 (5): 16–0672. doi:10.4269/ajtmh.16-0672. ISSN 0002-9637. PMC 5417190. PMID 28167595.
  19. Nachrichten, n-tv. "Unbekanntes Virus entdeckt". n-tv.de. Retrieved 20 December 2018.
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