Nocardiosis

Nocardiosis is an infectious disease affecting either the lungs (pulmonary nocardiosis) or the whole body (systemic nocardiosis). It is due to infection by a bacterium of the genus Nocardia, most commonly Nocardia asteroides or Nocardia brasiliensis.

Nocardiosis
SpecialtyInfectious disease 

It is most common in adult males, especially those with a weakened immune system. In patients with brain nocardia infection, mortality exceeds 80%; in other forms, mortality is 50%, even with appropriate therapy.[1]

It is one of several conditions that have been called "the great imitator".[2] Cutaneous nocardiosis commonly occurs in immunocompetent hosts.[3]

Signs and symptoms

Pulmonary infection

  • Produces a virulent form of pneumonia (progressive)
  • Night sweats, fever, cough, chest pain
  • Pulmonary nocardiosis is subacute in onset and refractory to treatment with standard antibiotics
  • Symptoms are more severe in immunocompromised individuals
  • Radiologic studies show multiple pulmonary infiltrates, with a tendency to central necrosis

Neurological infection

  • Headache, lethargy, confusion, seizures, sudden onset of neurological deficit
  • CT scan shows cerebral abscess
  • Nocardial meningitis is difficult to diagnose

Cardiac conditions

  • Nocardia has been highly linked to endocarditis as a main manifestation
  • In recorded cases, it has caused damage to heart valves whether natural or prosthetic[4][5]

Lymphocutaneous disease

  • Nocardial cellulitis is akin to erysipelas but is less acute
  • Nodular lymphangeitis mimics sporotrichosis with multiple nodules alongside a lymphatic pathway
  • Chronic subcutaneous infection is a rare complication and osteitis may ensue
  • May be misidentified and treated as a staph infection, specifically superficial skin infections[6]
  • Cultures must incubate more than 48 hours to guarantee an accurate test

Ocular disease

  • Very rarely, nocardiae cause keratitis
  • Generally there is a history of ocular trauma

Disseminated nocardiosis

  • Dissemination occurs through the spreading enzymes possessed by the bacteria
  • Disseminated infection can occur in very immunocompromised patients
  • It generally involves both lungs and brain
  • Fever, moderate or very high can be seen
  • Multiple cavitating pulmonary infiltrates develop
  • Cerebral abscesses arise later
  • Cutaneous lesions are very rarely seen
  • If untreated, the prognosis is poor for this form of disease

Causes

Normally found in soil, these organisms cause occasional sporadic disease in humans and animals throughout the world. Another well publicized find is that of Nocardia as part of the oral microflora. Nocardia spp. have been reported in the normal gingivae and periodontal pockets along with other species such as Actinomyces, Arthromyces and Streptomyces spp.[7]

The usual mode of transmission is inhalation of organisms suspended in dust. Another very common method is by traumatic introduction, especially in the jaw. This leads to the entrance of Nocardia into the blood stream and the propagation of its pathogenic effects. Transmission by direct inoculation through puncture wounds or abrasions is less common.[1] Generally, nocardial infection requires some degree of immune suppression.

A weakened immune system is a general indicator of a person who is more susceptible to nocardiosis, such as someone who already has a disease that weakens their immune system. Additionally, those with low T-cell counts or other complications involving T-cells can expect to have a higher chance of becoming infected. Besides those with weak immune systems, a local traumatic inoculation can cause nocardiosis, specifically the cutaneous, lymphocutaneous, and subcutaneous forms of the disease.[8][9] There is no racial pattern in the risk of becoming infected with Nocardiosis.

Diagnosis

Diagnosis of nocardiosis can be made by a doctor using various techniques. These techniques include, but are not limited to: a chest x-ray to analyze the lungs, a bronchoscopy, a brain/lung/skin biopsy, or a sputum culture. However, diagnosis may be difficult. Nocardiae are gram positive, weakly acid-fast, branching rod-shaped bacteria and can be visualized by a modified Ziehl–Neelsen stain such as the Fite-Faraco method. In the clinical laboratory, routine cultures may be held for insufficient time to grow nocardiae, and referral to a reference laboratory may be needed for species identification.[10] Pulmonary infiltration and pleural effusion are usually detected via x-ray.

Treatment

Nocardiosis requires at least 6 months of treatment, preferably with trimethoprim/sulfamethoxazole or high doses of sulfonamides. In patients who do not respond to sulfonamide treatment, other drugs, such as ampicillin, erythromycin, or minocycline, may be added.

Treatment also includes surgical drainage of abscesses and excision of necrotic tissue. The acute phase requires complete bed rest; as the patient improves, activity can increase.[1]

A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise.[10]

Prognosis

The prognosis of nocardiosis is highly variable. The state of the host's health, site, duration, and severity of the infection all play parts in determining the prognosis. Currently, skin and soft tissue infections have a 100% cure rate, and pleuropulmonary infections have a 90% cure rate with appropriate therapy. The cure rate falls to 63% with those infected with disseminated nocardiosis, with only half of patients surviving infections that cause brain abscess. Additionally, 44% of people who are infected in the spinal cord/brain die, increasing to 85% if that person has an already weakened immune system. There are no preventative treatments for nocardiosis. The only recommendation is to protect open wounds to limit entrance of the bacterium.

Epidemiology

Although there are no international data available on worldwide infection rates per year, there are roughly 500–1000 documented cases of nocardiosis per year in the US. Most of these cases occur in men, as there is a 3:1 ratio of male of female cases annually; however, this difference may be due to exposure frequency rather than susceptibility differences. From an age perspective, it is not highly more prevalent in one age group than another.[8] Cutaneous nocardiosis is slightly more common in middle aged men, but as a whole, all age groups are susceptible.[11] There is no racial pattern in the risk of becoming infected with nocardiosis.

References
  1. "Nocardiosis (Professional Guide to Diseases (Eighth Edition))—WrongDiagnosis.com". Retrieved 2007-07-12.
  2. Lederman ER, Crum NF (September 2004). "A case series and focused review of nocardiosis: clinical and microbiologic aspects". Medicine (Baltimore). 83 (5): 300–13. doi:10.1097/01.md.0000141100.30871.39. PMID 15342974. S2CID 23940448.
  3. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  4. "Nocardia Endocarditis in a Native Mitral Valve Revista Espanola de Cardiologia Volume 57, Issue 8, August 2004, Pages 787–788".
  5. "Successful Antimicrobial Chemotherapy for Nocardia Asteroides Prosthetic Valve Endocarditis The American Journal of Medicine, Volume 115, Issue 4, Pages 330–332".
  6. "Dermatologic Manifestations of Nocardiosis: Background, Pathophysiology, Epidemiology". 2016-09-27. Cite journal requires |journal= (help)
  7. Roth, GD; Thurn, AN (Nov–Dec 1962). "Continued study of oral nocardia". Journal of Dental Research. 41 (6): 1279–92. CiteSeerX 10.1.1.523.2905. doi:10.1177/00220345620410060401. PMID 13975308. S2CID 26640128.
  8. "Nocardiosis: Background, Pathophysiology, Epidemiology". 2016-07-25. Cite journal requires |journal= (help)
  9. Wilson, John W. (2016-11-10). "Nocardiosis: Updates and Clinical Overview". Mayo Clinic Proceedings. 87 (4): 403–407. doi:10.1016/j.mayocp.2011.11.016. ISSN 0025-6196. PMC 3498414. PMID 22469352.
  10. "Nocardiosis: DBMD—WrongDiagnosis.com". Retrieved 2007-07-12.
  11. "Dermatologic Manifestations of Nocardiosis: Background, Pathophysiology, Epidemiology". 2016-09-27. Cite journal requires |journal= (help)

Webmd article on Nocardiosis

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