NESS-040C5

NESS-040C5 is a potent cannabinoid agonist which was developed for the treatment of glaucoma.[1] It has reasonable selectivity for the CB₂ receptor subtype, having a CB₂ affinity of 0.4nM, and 25x selectivity over the related CB₁ receptor.[2]

NESS-040C5

Clinical data
ATC code	none
Legal status
Legal status	CA: Schedule II
Identifiers
IUPAC name N-(2-isopropyl-5-methylcyclohexyl)-1-(4-methylbenzyl)-1,4-dihydrothieno[3',2':4,5]cyclopenta[1,2-c]pyrazole-3-carboxamide
CAS Number	1445751-90-5
CompTox Dashboard (EPA)	DTXSID201010004
Chemical and physical data
Formula	C27H33N3OS
Molar mass	447.64 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(C=C1)=CC=C1CN2C3=C(CC4=C3SC=C4)C(C(NC5CC(C)CCC5C(C)C)=O)=N2

See also

• AB-FUBINACA
• NESS-0327
• SR-144,528

References

1. Paolo Lazzari et al. Pharmaceutical Compounds. US Patent 8106218
2. Hanus LO, Mechoulam R (2010). "Novel natural and synthetic ligands of the endocannabinoid system". Current Medicinal Chemistry. 17 (14): 1341–59. doi:10.2174/092986710790980096. PMID 20166928.