Mycobacterium obuense

Mycobacterium obuense
Scientific classification
Kingdom:	Bacteria
Phylum:	Actinobacteria
Order:	Actinomycetales
Suborder:	Corynebacterineae
Family:	Mycobacteriaceae
Genus:	Mycobacterium
Species:	M. obuense
Binomial name
	Mycobacterium obuense;

Mycobacterium obuense is a species of soil-dwelling scotochromogenic Mycobacterium.[1] The cell wall of M. obuense contains 1-tetradecanol, 2-octadecanol, and 2-eicosanol,[2] and triacylated lipoproteins.

Use in Immunomodulatory therapy

Preparations of heat-killed Mycobacterium obuense (such as IMM-101) are immunomodulatory and have been used to direct the immune response in the treatment of cancers - notably pancreatic cancer and malignant melanoma. Recent trials have been directed towards the treatment of colorectal cancer.[3] It has been shown that human myeloid dendritic cells, (antigen-presenting cells that serve as a bridge linking the adaptive and innate immune system), can detect mycobacterial triacylated lipoproteins via TLR2 and TLR1.[4]

References

Tsukamura, M; Mizuno, S (October 1971). "Mycobacterium obuense, a rapidly growing scotochromogenic mycobacterium capable of forming a black product from p-aminosalicylate and salicylate". J. Gen. Microbiol. 68 (2): 129–34. doi:10.1099/00221287-68-2-129. PMID 5136244.
P.L. Valero-Guillén, F. Martín-Luengo (1986). "1-Tetradecanol, a new alcohol found in the cell wall of some rapidly growing chromogenic mycobacteria". FEMS Microbiology Letters. 35: 59–63. doi:10.1111/j.1574-6968.1986.tb01499.x – via Oxford University Press.
"Clinical trials - new cancer treatment". Thelondonclinic.co.uk. 2012-04-25. Archived from the original on 2012-09-20. Retrieved 2012-10-04.
S. Bazzi, H. Modjtahedi, S. Mudan, M. Achkar, C., G.M. Bahr (2017). "Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells". Innate Immunity. 23 (7): 592–605. doi:10.1177/1753425917727838. PMID 28853313. S2CID 206788250.CS1 maint: multiple names: authors list (link)

External links

Type strain of Mycobacterium obuense at BacDive - the Bacterial Diversity Metadatabase

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[1] Tsukamura, M; Mizuno, S (October 1971). "Mycobacterium obuense, a rapidly growing scotochromogenic mycobacterium capable of forming a black product from p-aminosalicylate and salicylate". J. Gen. Microbiol. 68 (2): 129–34. doi:10.1099/00221287-68-2-129. PMID 5136244.

[2] P.L. Valero-Guillén, F. Martín-Luengo (1986). "1-Tetradecanol, a new alcohol found in the cell wall of some rapidly growing chromogenic mycobacteria". FEMS Microbiology Letters. 35: 59–63. doi:10.1111/j.1574-6968.1986.tb01499.x – via Oxford University Press.

[3] "Clinical trials - new cancer treatment". Thelondonclinic.co.uk. 2012-04-25. Archived from the original on 2012-09-20. Retrieved 2012-10-04.

[4] S. Bazzi, H. Modjtahedi, S. Mudan, M. Achkar, C., G.M. Bahr (2017). "Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells". Innate Immunity. 23 (7): 592–605. doi:10.1177/1753425917727838. PMID 28853313. S2CID 206788250.CS1 maint: multiple names: authors list (link)