MAP4K1

Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[5] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.[6]

MAP4K1
Identifiers
Aliases	MAP4K1, HPK1, mitogen-activated protein kinase kinase kinase kinase 1
External IDs	OMIM: 601983 MGI: 1346882 HomoloGene: 5199 GeneCards: MAP4K1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,587,641 bp[1] End 38,618,882 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 28,982,050 bp[2] End 29,003,279 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • MAP kinase kinase kinase kinase activity • protein serine/threonine kinase activity • nucleotide binding • GO:0001948 protein binding • ATP binding • kinase activity Cellular component • cytoplasm • membrane • intracellular Biological process • autophosphorylation • protein phosphorylation • response to stress • cellular proliferation • GO:0007243 intracellular signal transduction • activation of MAPKKK activity • activation of JUN kinase activity • peptidyl-serine phosphorylation • phosphorylation • regulation of mitotic cell cycle • regulation of apoptotic process • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity • cellular response to phorbol 13-acetate 12-myristate Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11184	26411
Ensembl	ENSG00000282928 ENSG00000104814	ENSMUSG00000037337
UniProt	Q92918	P70218
RefSeq (mRNA)	NM_001042600 NM_007181	NM_008279 NM_001355054
RefSeq (protein)	NP_001036065 NP_009112	NP_032305 NP_001341983
Location (UCSC)	Chr 19: 38.59 – 38.62 Mb	Chr 7: 28.98 – 29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MAP4K1 has been shown to interact with:

• B-cell linker,[7]
• CRK,[8][9][10]
• CRKL,[8][9][10]
• Drebrin-like,[11]
• GRAP2,[12]
• Grb2,[8][9][10][13]
• Linker of activated T cells,[10] and
• NCK1.[9][10][13]

References

1. ENSG00000104814 GRCh38: Ensembl release 89: ENSG00000282928, ENSG00000104814 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037337 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
6. Chuang, HC; Wang, X; Tan, TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advanced Immunology. Advances in Immunology. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862.
7. Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R, Kiefer F, Kitamura D (Aug 2001). "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. doi:10.1084/jem.194.4.529. PMC 2193495. PMID 11514608.
8. Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (Oct 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID 9788432.
9. Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (Feb 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. doi:10.1128/MCB.19.2.1359. PMC 116064. PMID 9891069.
10. Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (Jun 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. doi:10.1074/jbc.M101485200. PMID 11279207.
11. Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
12. Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.
13. Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T (Oct 1997). "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. doi:10.1074/jbc.272.44.27804. PMID 9346925.