Drebrin-like

Drebrin-like protein is a protein that in humans is encoded by the DBNL gene.[5][6]

DBNL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X67
Identifiers
Aliases	DBNL, ABP1, HIP-55, HIP55, SH3P7, Drebrin-like, drebrin like
External IDs	OMIM: 610106 MGI: 700006 HomoloGene: 8468 GeneCards: DBNL
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,044,640 bp[1] End 44,069,456 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 3.87 cM Start 5,788,488 bp[2] End 5,800,962 bp[2]
Gene ontology Molecular function • protein domain specific binding • protein C-terminus binding • GO:0001948 protein binding • GO:0010577 enzyme activator activity • actin filament binding • actin binding • cadherin binding Cellular component • endosome • Golgi apparatus • cell projection • GO:0097483, GO:0097481 postsynaptic density • membrane • Golgi membrane • cell membrane • synapse • intracellular • cell junction • dendrite • early endosome • clathrin-coated vesicle membrane • extracellular exosome • cytoskeleton • cytoplasmic vesicle • podosomes • lamellipodium • cytoplasm • ruffle • cell cortex • cytosol • extracellular region • secretory granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • endocytosis • adaptive immune response • activation of JUN kinase activity • immune system process • synapse assembly • neuron projection morphogenesis • podosome assembly • Rac protein signal transduction • neutrophil degranulation • receptor-mediated endocytosis • ruffle assembly • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28988	13169
Ensembl	ENSG00000136279	ENSMUSG00000020476
UniProt	Q9UJU6	Q62418
RefSeq (mRNA)	NM_001014436 NM_001122956 NM_001284313 NM_001284315 NM_014063 NM_001362723	NM_001146308 NM_001146309 NM_013810
RefSeq (protein)	NP_001014436 NP_001116428 NP_001271242 NP_001271244 NP_054782 NP_001349652	NP_001139780 NP_001139781 NP_038838
Location (UCSC)	Chr 7: 44.04 – 44.07 Mb	Chr 11: 5.79 – 5.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Drebrin-like has been shown to interact with Cyclin-dependent kinase 4,[7] MAP4K1[8] and ZAP-70.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000136279 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020476 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee CG, Morse HC, Kay BK, Kozak CA (May 1999). "Genetic mapping of eight SH3 domain genes on seven mouse chromosomes". Mamm Genome. 10 (4): 402–4. doi:10.1007/s003359901011. PMID 10087302. S2CID 11371043.
6. "Entrez Gene: DBNL drebrin-like".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
8. Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (Nov 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
9. Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (Dec 2003). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling". J. Biol. Chem. 278 (52): 52195–202. doi:10.1074/jbc.M305026200. PMID 14557276.

Further reading

• Gipson IK, Spurr-Michaud S, Moccia R, Zhan Q, Toribara N, Ho SB, Gargiulo AR, Hill JA (1999). "MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix". Biol. Reprod. 60 (1): 58–64. doi:10.1095/biolreprod60.1.58. PMID 9858486.
• Larbolette O, Wollscheid B, Schweikert J, Nielsen PJ, Wienands J (1999). "SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors". Mol. Cell. Biol. 19 (2): 1539–46. doi:10.1128/MCB.19.2.1539. PMC 116082. PMID 9891087.
• Ensenat D, Yao Z, Wang XS, Kori R, Zhou G, Lee SC, Tan TH (1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
• Yamazaki H, Takahashi H, Aoki T, Shirao T (2001). "Molecular cloning and dendritic localization of rat SH3P7". Eur. J. Neurosci. 14 (6): 998–1008. doi:10.1046/j.0953-816x.2001.01727.x. PMID 11595038. S2CID 15501009.
• Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mise-Omata S, Montagne B, Deckert M, Wienands J, Acuto O (2003). "Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference". Biochem. Biophys. Res. Commun. 301 (3): 704–10. doi:10.1016/S0006-291X(02)02972-8. PMID 12565838.
• Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL (2004). "Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape". Hum. Mol. Genet. 12 (16): 1981–93. doi:10.1093/hmg/ddg209. PMID 12913069.
• Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (2004). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling". J. Biol. Chem. 278 (52): 52195–202. doi:10.1074/jbc.M305026200. PMID 14557276.
• Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M (2004). "Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis". J. Biol. Chem. 279 (15): 15550–60. doi:10.1074/jbc.M312659200. PMID 14729663.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Denis FM, Benecke A, Di Gioia Y, Touw IP, Cayre YE, Lutz PG (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.
• Han J, Shui JW, Zhang X, Zheng B, Han S, Tan TH (2005). "HIP-55 is important for T-cell proliferation, cytokine production, and immune responses". Mol. Cell. Biol. 25 (16): 6869–78. doi:10.1128/MCB.25.16.6869-6878.2005. PMC 1190228. PMID 16055701.
• Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.