List of investigational antipsychotics

This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Receptor modulators

Monoamine receptor modulators

• ATI-9242 – atypical antipsychotic (D₂ and 5-HT_2A receptor antagonist, other actions)[1]
• AVN-211 (CD-008-0173) – 5-HT₆ receptor antagonist[2]
• Brilaroxazine (RP-5063, RP-5000; oxaripiprazole) – atypical antipsychotic (D₂ receptor partial agonist, 5-HT_2A receptor antagonist, other actions)[3]
• F-17464 – D₃ receptor antagonist, 5-HT_1A receptor partial agonist, and weak D₂ receptor partial agonist[4]
• FKF-02SC (TGOF-02N) – atypical antipsychotic (D₂ and 5-HT_2A receptor antagonist, other actions)[5]
• Lu-AF35700 – D₁, 5-HT_2A, and 5-HT₆ receptor antagonist[6]
• Masupirdine (SUVN-502) – 5-HT₆ receptor antagonist[7]
• SEP-363856 (SEP-856) – 5-HT_1A receptor and TAAR1 agonist[8]
• SUVN-D4010 – 5-HT₄ receptor partial agonist[9]
• TAK-058 (ENV-8058) – 5-HT₃ receptor antagonist[10]

Glutamate receptor modulators

• Neboglamine (CR-2249, XY-2401; nebostinel) – NMDA receptor glycine-site positive allosteric modulator[11]
• PF-4958242 – AMPA receptor positive allosteric modulator[12]
• Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR₂ and mGluR₃ agonist[13]

Acetylcholine receptor modulators

• APN-1125 – α₇ nicotinic acetylcholine receptor partial agonist[14]
• Trospium chloride/xanomeline (KarXT) – combined M₁ and M₄ muscarinic acetylcholine receptor agonist and peripherally-selective muscarinic acetylcholine receptor antagonist[15]

Cannabinoid receptor modulators

• AX-1604 – cannabinoid receptor modulator (phytocannabinoid-based chewing gum)[16]
• Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions[17][18]

Other/mixed receptor modulators

• Basmisanil (RG-1662, RO-5186582) – GABA_A receptor α₅ subunit-containing negative allosteric modulator[19]
• Deudextromethorphan (d-DM; AVP-786, CTP-786) – σ₁ receptor agonist, serotonin–norepinephrine reuptake inhibitor, uncompetitive NMDA receptor antagonist, other actions[20]
• Erteberel (LY-500307, SERBA-1) – ERβ agonist[21]
• Olanzapine/samidorphan (ALKS-3831) – combined atypical antipsychotic (D₂ and 5-HT_2A receptor antagonist, other actions) and μ-opioid receptor antagonist[22]
• Roluperidone (CYR-101, MIN-101, MT-210) – 5-HT_2A and σ₂ receptor antagonist[23]

Enzyme inhibitors

• BI-409306 (SUB-166499) – phosphodiesterase 9A inhibitor[24]
• Lu-AF11167 – dual phosphodiesterase 2A and 10A inhibitor[25]
• OMS-824 (OMS-643762) – phosphodiesterase 10A inhibitor[26]
• Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D-amino acid oxidase inhibitor[27]
• TAK-831 – D-amino acid oxidase inhibitor[28]

Ion channel modulators

• AUT-00206 – shaw potassium channel modulator[29]
• Evenamide (NW-3509; NW-3509A) – Na_v1.3, Na_v1.7, and Na_v1.8 voltage-gated sodium channel blocker[30]

Others

• ADE-615 – undefined mechanism of action[31]
• ADE-616 – undefined mechanism of action[32]
• AMG-581 – undefined mechanism of action[33]
• ASP-4345 – undefined mechanism of action[34]
• ASP-6981 – undefined mechanism of action[35]
• ATx11-004 – undefined mechanism of action[36]
• MK-8189 – undefined mechanism of action[37]
• PF-06266047 – undefined mechanism of action[38]
• Pyridoxamine (BST-4001, K-163, K-163SZ; Pyridorin) – vitamin B₆, advanced glycosylation end-product inhibitor, oxygen radical scavenger[39]
• TS-134 (TS-1341) – undefined mechanism of action[40]

See also

• List of investigational drugs

References

1. "ATI 9242 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
2. "AVN 211 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
3. "Brilaroxazine - Reviva Biopharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
4. "F 17464 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
5. "FKF 02SC - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
6. "Lu AF35700 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
7. "Masupirdine - Suven Life Sciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
8. "SEP 363856 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
9. "SUVN D4010 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
10. "TAK 058 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
11. "Neboglamine - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
12. "BIIB 104 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
13. "Pomaglumetad methionil - Denovo Biopharma/Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
14. "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
15. "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
16. "AX 1604 - Axim Biotech - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
17. "Cannabidiol - GW Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
18. "Cannabidiol - Echo Pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved 14 February 2020.
19. "Basmisanil - Roche - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
20. "Deudextromethorphan - Avanir Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
21. "Erteberel - Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
22. "Olanzapine/samidorphan - Alkermes plc - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
23. "Roluperidone - Minerva Neurosciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
24. "BI 409306 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
25. "Lu AF11167 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
26. "OMS 824 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
27. "Sodium benzoate - SyneuRx - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
28. "TAK 831 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
29. "AUT 00206 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
30. "Evenamide - Newron Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
31. "ADE 615 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
32. "ADE 616 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
33. "AMG 581 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
34. "ASP 4345 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
35. "ASP 6981 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
36. "Atx11 004 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
37. "MK 8189 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
38. "PF 06266047 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
39. "Pyridoxamine - NephroGenex/Kowa - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
40. "TS 134 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.

External links

• AdisInsight – Springer
• 2016 Medicines in Development for Mental Health – PhRMA