Liquiritin

Liquiritin is the 4'-O-glucoside of the flavanone liquiritigenin. Liquiritin is one of flavone compounds derived from licorice.[1]

Liquiritin

Names
Other names Liquiritoside Liquiritigenin-4'-O-glucoside
Identifiers
CAS Number	551-15-5
3D model (JSmol)	Interactive image
ChEBI	CHEBI:80845
ChemSpider	439855
PubChem CID	503737
UNII	T0O79T74CD
CompTox Dashboard (EPA)	DTXSID40203619
InChI InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1 Key: DEMKZLAVQYISIA-ZRWXNEIDSA-N InChI=1/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1 Key: DEMKZLAVQYISIA-ZRWXNEIDBX
SMILES C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
Properties
Chemical formula	C21H22O9
Molar mass	418.398 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

De novo biosynthesis of liquiritin in Saccharomyces cerevisiae using endogenous yeast metabolites as precursors and cofactors, provides a possibility for the economical and sustainable production and application of licorice flavonoids through synthetic biology.[2]

References

1. Cong JX, Wang SY, Wu XH, Yu P (2012). "Optimization of Separation Conditions of Liquiritin in Preparative Liquid Chromatography". Advanced Materials Research. 550–553: 1647–1652. doi:10.4028/www.scientific.net/AMR.550-553.1647. S2CID 97214921.
2. Yin Y, Li Y, Jiang D, Zhang X, Gao W, Liu C (April 2020). "De novo biosynthesis of liquiritin in Saccharomyces cerevisiae". Acta Pharmaceutica Sinica. B. 10 (4): 711–721. doi:10.1016/j.apsb.2019.07.005. PMC 7161706. PMID 32322472.

Further reading

• Wang J, Wang D, Yu J, Liu C, Li L, Zhang Y (April 2014). "Isolation of liquiritigenin-4'-apiosyl-glucoside and liquiritin from the root of Glycyrrhiza uralensis by high-performance centrifugal partition chromatography". Journal of Chromatographic Science. 52 (4): 310–4. doi:10.1093/chromsci/bmt029. PMID 23552847.
• Cong, Jing Xiang; Wang, Shao Yan; Gao, Hong (2012). "Separation of Liquiritin by Two-Dimensional Liquid Chromatography". Advanced Materials Research. 455–456: 1232–1238. doi:10.4028/www.scientific.net/AMR.455-456.1232. ISSN 1662-8985. S2CID 135570958.
• Cong J, Lin B (March 2007). "Separation of Liquiritin by simulated moving bed chromatography". Journal of Chromatography A. 1145 (1–2): 190–4. doi:10.1016/j.chroma.2007.01.088. PMID 17289063.
• Ni H, Xu M, Xie K, Fei Y, Deng H, He Q, Wang T, Liu S, Zhu J, Xu L, Yao M (2020). "Liquiritin Alleviates Pain Through Inhibiting CXCL1/CXCR2 Signaling Pathway in Bone Cancer Pain Rat". Frontiers in Pharmacology. 11: 436. doi:10.3389/fphar.2020.00436. PMC 7193085. PMID 32390832.

External links

• Media related to Liquiritin at Wikimedia Commons