Julie Ahringer

Julie Ann Ahringer FMedSci is an American/British Professor of Genetics and Genomics, Director of the Gurdon Institute and a member of the Department of Genetics at the University of Cambridge.[9][10][8][11][12] She leads a research lab investigating the control of gene expression.[9]

Julie Ahringer

FMedSci
Born
Julie Ann Ahringer
NationalityAmerican
Alma mater
Known forRNA interference[1]
Caenorhabditis elegans[2][3][4][5][6]
Spouse(s)
​
(m. 1996)​
[7]
Awards
Scientific career
Fields
InstitutionsGurdon Institute
University of Cambridge
Laboratory of Molecular Biology
University of Wisconsin–Madison
ThesisPost-transcriptional regulation of fem-3, a sex-determining gene of Caenorhabditis elegans (1991)
Doctoral advisorJudith Kimble
Other academic advisorsJohn Graham White
Websitewww.gurdon.cam.ac.uk/ahringer.html

Her laboratory carried out the first systematic inactivation of the majority of genes in an animal through constructing and screening a genome-wide RNA interference library for the nematode worm Caenorhabditis elegans.[13] Research in Ahringer's lab investigates the control of gene expression and genome architecture in development, using C. elegans as a model system.[14]

Education

Ahringer is from Miami, Florida[15] and was educated at Lafayette College in Easton, Pennsylvania where she was awarded a Bachelor of Arts degree in Chemistry in 1984.[16] She completed her PhD at the University of Wisconsin–Madison while working with Judith Kimble.[17][18][19]

Research and career

After her Phd, she carried out postdoctoral research at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge with John Graham White.[20] Ahringer became a group leader in the department of genetics in Cambridge in 1996, before moving to the Gurdon Institute in 1998.[21] Her laboratory carried out the first systematic inactivation of the majority of genes in any animal by constructing and screening a genome-wide RNAi library for Caenorhabditis elegans (C. elegans). Ahringer's research group studies the regulation of chromatin structure and function in gene expression and genome organization using the nematode C. elegans as a model to understand development and disease. The Ahringer Lab research is funded by the Wellcome Trust.[9]

Honors and awards

Ahringer was elected to the EMBO Membership in 2003[22] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2007.[23] She delivered the Francis Crick lecture prize of the Royal Society in 2004.[24] In 2020 she was awarded the George W. Beadle Award of the Genetics Society of America for outstanding contributions to genetics.[25]

She serves as a member of the scientific advisory board of the Medical Research Council (MRC) along with many other eminent scientists.[26]

Personal life

Ahringer married Richard Durbin in 1996, with whom she has two children.[7]

References
  1. Qu, W.; Ren, C.; Li, Y.; Shi, J.; Zhang, J.; Wang, X.; Hang, X.; Lu, Y.; Zhao, D.; Zhang, C. (2011). "Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: A guide for genome-wide screens". BMC Genomics. 12: 170. doi:10.1186/1471-2164-12-170. PMC 3087708. PMID 21453524.
  2. Kamath, R.; Fraser, A.; Dong, Y.; Poulin, G.; Durbin, R.; Gotta, M.; Kanapin, A.; Le Bot, N.; Moreno, S.; Sohrmann, M.; Welchman, D. P.; Zipperlen, P.; Ahringer, J. (2003). "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi". Nature. 421 (6920): 231–237. Bibcode:2003Natur.421..231K. doi:10.1038/nature01278. PMID 12529635. S2CID 15745225.
  3. Ahringer, J.; Kamath, A. G.; Zipperlen, R. S.; Martinez-Campos, P.; Sohrmann, M.; Ahringer, M. (2000). "Functional genomic analysis of C. Elegans chromosome I by systematic RNA interference". Nature. 408 (6810): 325–330. Bibcode:2000Natur.408..325F. doi:10.1038/35042517. PMID 11099033. S2CID 4373444.
  4. Murphy, C. T.; McCarroll, S. A.; Bargmann, C. I.; Fraser, A.; Kamath, R. S.; Ahringer, J.; Li, H.; Kenyon, C. (2003). "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans". Nature. 424 (6946): 277–283. Bibcode:2003Natur.424..277M. doi:10.1038/nature01789. PMID 12845331. S2CID 4424249.
  5. Ashrafi, K.; Chang, F. Y.; Watts, J. L.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2003). "Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes". Nature. 421 (6920): 268–272. Bibcode:2003Natur.421..268A. doi:10.1038/nature01279. PMID 12529643. S2CID 4321264.
  6. Lee, S. S.; Lee, R. Y. N.; Fraser, A. G.; Kamath, R. S.; Ahringer, J.; Ruvkun, G. (2002). "A systematic RNAi screen identifies a critical role for mitochondria in C. Elegans longevity". Nature Genetics. 33 (1): 40–48. doi:10.1038/ng1056. PMID 12447374. S2CID 17681940.
  7. Anon (2006). "Durbin, Richard Michael". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.U45024. (subscription or UK public library membership required)
  8. Julie Ahringer publications indexed by Google Scholar
  9. Florence Leroy based on Custom Repute template. "Home | Ahringer Lab". Gurdon.cam.ac.uk. Archived from the original on 2016-10-17. Retrieved 2016-12-19.
  10. Julie Ahringer's publications indexed by the Scopus bibliographic database. (subscription required)
  11. Julie Ahringer publications from Europe PubMed Central
  12. Pocock, R.; Ahringer, J.; Mitsch, M.; Maxwell, S.; Woollard, A. (2004). "A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. Elegans". Development. 131 (10): 2373–2385. doi:10.1242/dev.01110. PMID 15102704.
  13. "Outstanding Women In Science Seminar series: Julie Ahringer". NCCR in Chemical Biology. Retrieved 2019-04-06.
  14. "Ahringer Lab — The Gurdon Institute". www.ahringer.group.gurdon.cam.ac.uk/. Retrieved 2020-12-10.
  15. Call, The Morning. "PROFESSOR GETS GRANT FOR CHEMICAL RESEARCH". themorningcall.com. Retrieved 2019-04-06.
  16. Julie Ahringer ORCID 0000-0002-7074-4051
  17. Ahringer, Julie Ann (1991). Posttranscriptional regulation offem-3, a sex-determining gene of Caenorhabditis elegans (PhD thesis). University of Wisconsin–Madison. ProQuest 303972449.
  18. Ahringer, J.; Rosenquist, T. A.; Lawson, D. N.; Kimble, J. (1992). "The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally". The EMBO Journal. 11 (6): 2303–2310. doi:10.1002/j.1460-2075.1992.tb05289.x. PMC 556697. PMID 1376249.
  19. Ahringer, J.; Kimble, J. (1991). "Control of the sperm–oocyte switch in Caenorhabditis elegans hermaphrodites by the fem-3 3′ untranslated region". Nature. 349 (6307): 346–348. Bibcode:1991Natur.349..346A. doi:10.1038/349346a0. PMID 1702880. S2CID 4304843.
  20. Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003). "The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus". Cell. 115 (7): 825–836. doi:10.1016/S0092-8674(03)00985-1. PMID 14697201. S2CID 2605372.
  21. "Science Advisory Board | Julie Ahringer". LMS London Institute of Medical Sciences. Retrieved 2019-04-06.
  22. "Find People in the EMBL Communities". 2017. Retrieved 2018-10-09.
  23. "Professor Julie Ahringer | The Academy of Medical Science". Retrieved 2018-10-09.
  24. Ahringer, Julie (2004). "Genes, worms and the new genetics". royalsociety.org. London: Royal Society.
  25. "Congratulations to the recipients of the 2020 GSA Awards!". Genetics Society of America. Retrieved 5 February 2020.
  26. "Scientific Advisory Board". Csc.mrc.ac.uk. Archived from the original on 2012-07-03. Retrieved 2016-12-19.
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