Isopropyl nitrite

Isopropyl nitrite
Clinical data
Other names	Isopropyl alcohol nitrite; nitrous acid, isopropyl ester; 1-methylethyl nitrite; 2-propyl nitrite
ATC code	None;
Identifiers
	IUPAC name 2-propyl nitrite;
CAS Number	541-42-4 ;
PubChem CID	10929;
ChemSpider	10466 ;
UNII	2T3Y2PS0ZE;
CompTox Dashboard (EPA)	DTXSID3052191 ;
ECHA InfoCard	100.007.982
Chemical and physical data
Formula	C3H7NO2
Molar mass	89.09 g·mol−1
3D model (JSmol)	Interactive image;
Density	0.8684 g/cm3
Boiling point	40 °C (104 °F)
	SMILES O=NOC(C)C;
	InChI InChI=1S/C3H7NO2/c1-3(2)6-4-5/h3H,1-2H3 ; Key:SKRDXYBATCVEMS-UHFFFAOYSA-N ;
	(verify)

The chemical compound isopropyl nitrite (or 2-propyl nitrite) is an alkyl nitrite made from isopropanol. It is a clear pale yellow oil.[1]

Isopropyl nitrite in a glass bottle

Applications

Isopropyl nitrite is one of the compounds used as poppers, an inhalant drug that induces a brief euphoria. Isopropyl nitrite has largely replaced isobutyl nitrite in poppers.

Safety

Isopropyl nitrite has been associated with eye maculopathy, visual impairment with central scotomata, bilateral foveal yellow spots, and inner segment/outer segment (IS/OS) junction disruption,[2] which may be reversible.[3]

The compound may also be potentially harmful to human body—inhaling isopropyl nitrite (and other alkyl nitrites) vapor can dilate the sphincter muscles and cause headaches and extremely low blood pressure as well as increased body temperature, even death.

References

Handbook of Chemistry and Physics, CRC Press, 85th edition
Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–86. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.
Inserm. "Des pertes visuelles chez les consommateurs de poppers". www.inserm.fr (in French). Archived from the original on 2012-06-05. Retrieved 2017-01-23.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Handbook of Chemistry and Physics, CRC Press, 85th edition

[2] Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–86. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.

[3] Inserm. "Des pertes visuelles chez les consommateurs de poppers". www.inserm.fr (in French). Archived from the original on 2012-06-05. Retrieved 2017-01-23.