Isojacareubin

Isojacareubin is a xanthonoid natural product found in Hypericum japonicum.[1]

Isojacareubin

Names
IUPAC name 6,10,11-Trihydroxy-3,3-dimethyl-1,2-dihydropyrano[2,3-c]xanthen-7-one
Identifiers
3D model (JSmol)	Interactive image
ChemSpider	28514885
PubChem CID	70697351
InChI InChI=1S/C18H16O6/c1-18(2)6-5-8-12(24-18)7-11(20)13-14(21)9-3-4-10(19)15(22)17(9)23-16(8)13/h3-4,7,19-20,22H,5-6H2,1-2H3 Key: NNWFEKLCJFLWGN-UHFFFAOYSA-N
SMILES CC1(CCC2=C3C(=C(C=C2O1)O)C(=O)C4=C(O3)C(=C(C=C4)O)O)C
Properties
Chemical formula	C18H16O6
Molar mass	328.320 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

It has been shown to have antibacterial activity. Isojacareubin also inhibits Protein Kinase C isoforms, and has activity against hepatocellular carcinoma.[2]

References

1. Zuo, GY; An, J; Han, J; Zhang, YL; Wang, GC; Hao, XY; Bian, ZQ (2012). "Isojacareubin from the Chinese Herb Hypericum japonicum: Potent Antibacterial and Synergistic Effects on Clinical Methicillin-Resistant Staphylococcus aureus (MRSA)". International Journal of Molecular Sciences. 13 (7): 8210–8. doi:10.3390/ijms13078210. PMC 3430230. PMID 22942699.
2. Xing Yuan, Hao Chen, Xia Li, Ming Dai, Huawu Zeng, Lei Shan, Qingyan Sun & Weidong Zhang (2015). "Inhibition of protein kinase C by isojacareubin suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo". Scientific Reports. 5: 12889. doi:10.1038/srep12889. PMC 4526861. PMID 26245668.CS1 maint: multiple names: authors list (link)