HLA-DR11
HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.
 | |
major histocompatibility complex, class II, DR11 | |
| Haplotypes groups | DQA*01:DRB1*1101 to DQA*01:DRB1*1111 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1101 to *1110 |
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*1101 |
| EBI-HLA | DRB1*1102 |
| EBI-HLA | DRB1*1103 |
| EBI-HLA | DRB1*1104 |
| EBI-HLA | DRB1*1105 |
| EBI-HLA | DRB1*1106 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR11 | DR5 | DR12 | Sample |
| allele | % | % | % | size (N) |
| 1101 | 92 | 5 | 3474 | |
| 1102 | 89 | 3 | 430 | |
| 1103 | 89 | 4 | 397 | |
| 1104 | 87 | 4 | 2119 | |
| 1105 | 75 | 4 | ||
| 1106 | 20 | 73 | 15 | |
| 1107 | >50 | 1 | ||
| 1108 | >50 | 2 | ||
| 1109 | 80 | 20 | 5 | |
The table above describes the efficiency of serological typing of DR11 and DR5. Serotypes are unknown the following alleles: DRB1*1110 to *1157
Disease associations
By serotype
DR11 is associated with grape anaphylaxis,[2] well-differentiated thyroid cancer,[3] low antibody production in Hepatitis C.[4]
By allele(s)
DRB1*11 is associated systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody [5]
DRB1*1101 is associated Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus,[6] mite sensitive asthma,[7] cervical cancer risk (HPV?)[8]
DRB1*1102: Tiopronin intolerance in rheumatoid arthritis[9]
DRB1*1104: pauciarticular juvenile rheumatoid arthritis [10]
By haplotype
DR11 is an identifier for the DR11-DQ7/DR7-DQ2 transhaplotype isoform of celiac disease.[11] DR11-DQ7.5 is identified as a risk factor in rheumatic heart disease.[12]
DRB1*1101:DQA1*0505:DQB1*0301 haplotype is associated with Anti-Ro/SSA with anti-La/SSB antibodies in neonatal lupus erythematosus,[6] mite sensitive asthma[7]
DRB1*1102:DQA1*0505:DQB1*0301 haplotype is associated with hepatitis B virus persistence[13]
Genetic Linkage
DR11 Haplotypes | ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR11(5)-DR52 | *0101 | *1101 | *02 | |
| *0101 | *1102 | *02 | ||
| *0101 | *1103 | *02 | ||
| *0101 | *1104 | *02 | ||
| Serotypes | DRB1 | DQA1 | DQB1 | |
| DR11(5)-DQ7 (7.5, 3) | *1101 | *0505 | *0301 | |
| *1102 | *0505 | *0301 | ||
| *1103 | *0505 | *0301 | ||
| *1104 | *0505 | *0301 | ||
| Serotypes | HLA-A | HLA-C | HLA-B | DRB1 |
| A2-Cw7-B18-DR11 | *0201 | *0701 | *1801 | *1104 |
| A24(9)-Cw4-B35-DR11 | *2402 | *0401 | *3501 | *1101 |
| A24(9)-Cw14(BL)-B51(5)-DR11 | *2402 | *1402 | *5101 | *1104 |
HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) serotypes. The frequency node for DR11 is in the Levant and Anatolia. This serotype more than others appears to have spread with neolithization of Western Europe. The closely linked DQ7.5 appears to be protective against juvenile diabetes, in which wheat consumption appears to be a risk factor.
References
- derived from IMGT/HLA
- Kalogeromitros D, Makris M, Gregoriou S, Mousatou V, Lyris N, Tarassi K, Papasteriades C (2005). "Grape anaphylaxis: a study of 11 adult onset cases". Allergy Asthma Proc. 26 (1): 53–8. PMID 15813289.
- Juhasz F, Kozma L, Stenszky V, Gyory F, Luckas G, Farid N (2005). "Well differentiated thyroid carcinoma is associated with human lymphocyte antigen D-related 11 in Eastern Hungarians: a case of changing circumstances". Cancer. 104 (8): 1603–8. doi:10.1002/cncr.21382. PMID 16121403.
- Hu C, Wu C, Lee C, Wu C, Tsai H, Chen P, Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C." Ann Rheum Dis. 65 (1): 138–9. doi:10.1136/ard.2005.039982. PMC 1797994. PMID 16344504.
- Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
- Miyagawa S, Shinohara K, Kidoguchi K, Fujita T, Fukumoto T, Hashimoto K, Yoshioka A, Shirai T (1997). "Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers". Autoimmunity. 26 (2): 95–101. doi:10.3109/08916939709003852. PMID 9546818.
- Lara-Marquez M, Yunis J, Layrisse Z, Ortega F, Carvallo-Gil E, Montagnani S, Makhatadze N, Pocino M, Granja C, Yunis E (1999). "Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population". Clin Exp Allergy. 29 (1): 60–71. doi:10.1046/j.1365-2222.1999.00461.x. PMID 10051703.
- Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731.
- Ju L, Paolozzi L, Delecoeuillerie G, Bourgeois P, Khodja M, Legoff P, Liote F, Sheffer V, Amor B, Charron D (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin Exp Rheumatol. 12 (3): 249–54. PMID 7915222.
- Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
- Tighe M, Hall M, Barbado M, Cardi E, Welsh K, Ciclitira P (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population". Tissue Antigens. 40 (2): 90–7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780.
- Chou HT, Chen CH, Chen JY, Chang KC (2007). "Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan". International Journal of Cardiology. 128 (3): 434–5. doi:10.1016/j.ijcard.2007.06.032. PMID 17673320.
- Thio C, Carrington M, Marti D, O'Brien S, Vlahov D, Nelson K, Astemborski J, Thomas D (1999). "Class II HLA alleles and hepatitis B virus persistence in African Americans". J Infect Dis. 179 (4): 1004–6. doi:10.1086/314684. PMID 10068598.