HLA-Cw4
HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.
| HLA-Cw4 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (MHC Class I, C cell surface antigen) | ||||||||||||||||
 HLA-Cw4 | ||||||||||||||||
| About | ||||||||||||||||
| Protein | transmembrane receptor/ligand | |||||||||||||||
| Structure | αβ heterodimer | |||||||||||||||
| Subunits | HLA-Cw*04--, β2-microglobulin | |||||||||||||||
| Older names | - | |||||||||||||||
| Subtypes | ||||||||||||||||
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| Rare alleles | ||||||||||||||||
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| Alleles link-out to IMGT/HLA database at EBI | ||||||||||||||||
Serotype
| Cw*04 | Cw4 | Cw403 | Cw6 | Sample |
| allele | % | % | % | size (N) |
| *0401 | 98 | 0 | 0 | 736 |
| *0403 | 37 | 5 | 17 | 25 |
Alleles
| Study population | Freq. (in %)[3] |
|---|---|
| Mexico Mixe Oaxaca | 37.8 |
| Mexico Mixtec Oaxaca | 37.3 |
| USA N. Mexico Canoncito N… | 31.7 |
| Mexico Zaptotec Oaxaca | 30.6 |
| Iran Baloch | 28.6 |
| Australia Indig. Cape Yor… | 27.5 |
| Australia Indig.Yuendumu | 26.8 |
| Australia Indig. Groote E… | 25.3 |
| Lebanon | 24.3 |
| Israel Arab Druse | 22.5 |
| Georgia Tibilisi Kurds | 22.4 |
| Brazil Terena | 22.3 |
| Georgia Tibilisi Georgian… | 22.0 |
| India Tamil Nadu Nadar | 21.3 |
| Mali Bandiagara | 21.3 |
| Taiwan Ami | 20.9 |
| Papua New Guinea Wanigela | 20.8 |
| USA African Americans pop… | 19.6 |
| Senegal Niokholo Mandenka | 19.5 |
| Cameroon Beti | 18.7 |
| Indig. Australian Kimberl… | 17.9 |
| Papua New Guinea Wosera | 17.0 |
| Italy North pop 1 | 16.7 |
| New Caledonia | 16.7 |
| Morocco Nador Metalsa (be… | 15.9 |
| Portugal Centre pop 2 | 15.8 |
| Cameroon Sawa | 15.4 |
| India Mumbai Marathas | 15.4 |
| Iran Tehran | 15.4 |
| USA Hispanic | 15.0 |
| PNG West Schrader Ranges | 14.8 |
| Zimbabwe Harare Shona | 14.8 |
| Swiss Geneva | 14.5 |
| Zambia Lusaka | 14.4 |
| Uganda Kampala | 14.1 |
| Brazil | 13.7 |
| Sudanese | 13.5 |
| France West | 13.4 |
| Tibetan | 13.3 |
| Finland | 13.3 |
| Kenya Luo | 13.2 |
| Cameroon Bamileke | 13.0 |
| Philippines Ivatan | 13.0 |
| Kenya | 12.9 |
| Singapore Riau Malay | 12.2 |
| India North Delhi | 11.7 |
| Tunisia | 11.6 |
| Kenya Nandi | 11.5 |
| Russia Tuva pop 2 | 11.5 |
| Taiwan Bunun | 11.4 |
| USA Caucasian pop2 | 11.1 |
| India West Coast Parsis | 11.0 |
| China Qinghai Hui | 10.9 |
| Czech Republic | 10.8 |
| India New Delhi | 10.7 |
| Spain Eastern Andalusia | 10.4 |
| UK Caucasians | 10.1 |
| Cameroon Pygmy Baka | 10.0 |
| China Beijing | 10.0 |
| Jordan Amman | 10.0 |
| Singapore Javanese | 10.0 |
| Papua New Guinea Madang | 9.5 |
| Saudi Arabia Guraiat and … | 9.5 |
| Australia New South Wales | 9.4 |
| USA Alaska Yupik Natives | 9.3 |
| Bulgaria Gipsy | 9.1 |
| Mex. Chihuahua Tarahumara | 9.1 |
| German Essen | 9.0 |
| France South East | 8.9 |
| Taiwan Paiwan | 8.8 |
| China Inner Mongolia | 8.3 |
| Ireland Northern | 8.3 |
| Venezuela Perija Yucpa | 8.3 |
| South Korea (1) | 8.2 |
| China North Han | 7.6 |
| USA South Dakota Lakota S… | 7.4 |
| Taiwan Atayal | 7.1 |
| India West Bhils | 7.0 |
| PNG Karimui Plateau | 6.9 |
| Taiwan Siraya | 6.9 |
| Taiwan Thao | 6.7 |
| Japan (5) | 6.5 |
| Thailand | 6.0 |
| China Guangzhou | 5.6 |
| USA Asian | 5.6 |
| Ireland South | 5.4 |
| PNG Eastern Highlands Gor… | 4.7 |
| Japan Central | 4.6 |
| Spain Eastern Andalusia G… | 4.5 |
| China South Han | 4.4 |
| South Africa Natal Tamil | 4.2 |
| American Samoa | 4.0 |
| Taiwan Saisiat | 3.9 |
| Papua New Guinea New Brit… | 3.6 |
| Taiwan Minnan pop 1 | 3.4 |
| USA Hawaii Okinawa | 3.3 |
| China Guangdong Meizhou H… | 3.0 |
| India Khandesh Pawra | 3.0 |
| Taiwan Puyuma | 3.0 |
| Allele frequencies presented, only | |
| Study population | Freq. (in %)[3] |
|---|---|
| PNG West Schrader Ranges | 45.9 |
| Taiwan Tao | 40.0 |
| PMG Eastern Highlands Gor… | 34.9 |
| PNG Madang | 25.0 |
| PNG Wanigela | 16.0 |
| Australia Indig. Cape Yor… | 15.7 |
| Australia Indig. Yuendumu | 15.1 |
| Australia Indig. Groote E… | 12.3 |
| Taiwan Puyuma | 12.0 |
| PNG Karimui Plateau | 11.9 |
| Taiwan Pazeh | 11.8 |
| Taiwan Thao | 11.7 |
| New Caledonia | 11.1 |
| Singapore Riau Malay | 9.8 |
| PNG New Britain Rabaul | 8.9 |
| PNG Wosera | 8.0 |
| Singapore Javanese | 7.0 |
| Taiwan Rukai | 7.0 |
| Taiwan Bunun | 6.4 |
| American Samoa | 6.0 |
| Thailand | 5.3 |
| Philippines Ivatan | 5.0 |
| Taiwan Siraya | 4.9 |
| Taiwan Tsou | 4.9 |
| Australia Indig. Kimberly | 3.6 |
| Taiwan Atayal | 3.3 |
| South Africa Natal Tamil | 3.1 |
| Taiwan Ami | 2.6 |
| China South Han | 2.1 |
| USA Asian | 2.0 |
| Taiwan Hakka | 1.8 |
| China Qinghai Hui | 1.4 |
| Iran Tehran | 1.3 |
| China Guangdong Meizhou H… | 1.0 |
| China Inner Mongolia | 1.0 |
| India West Coast Parsis | 1.0 |
| Taiwan Minnan pop 1 | 1.0 |
| Taiwan Paiwan | 1.0 |
| India New Delhi | 0.9 |
| Russia Tuva | 0.9 |
| China Tibetan | 0.6 |
| Allele frequencies presented, only | |
References
- Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- Allele Query Form IMGT/HLA - European Bioinformatics Institute
- Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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