HLA-A66

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁶ subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

HLA-A66
(MHC Class I, A cell surface antigen)
HLA-A66
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*66--, β2-microglobulin
Older names	A10
Subtypes
Subtype allele Available structures A66.1 *6601 A66.2 *6602 {{{cNick3}}} *66{{{cAllele3}}} {{{cNick4}}} *66{{{cAllele4}}}
Rare alleles
Subtype allele Available structures A66.3 *6603 {{{rnick2}}} *66{{{rallele2}}} {{{rnick3}}} *66{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype

A66 recognition of some HLA A*66 gene products[3]

A*66	A66	A10	A26	A34	Sample
allele	%	%	%	%	size (N)
*6601	20	10	61	8	799
*6602	38	10	4	27	205
*6603	32	7	7	18	28

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.

A*6601 Frequencies

HLA A*6601 frequencies

		freq
ref.	Population	(%)
[4]	Cameroon Sawa	7.7
[4]	Kenya Luo	6.8
[4]	Cameroon Sawa	7.7
[4]	Cameroon Bakola Pygmy	5.8
[4]	Cameroon Baka Pygmy	5.0
[4]	Kenya Nandi	5.0
[4]	Zimbabwe Harare Shona	0.2
[4]	Cameroon Baka Pygmy	5.0
[4]	Cameroon Beti	4.6
[4]	Cameroon Bamileke	4.5
[4]	India West Bhils	4.0
[4]	Zimbabwe Harere Shona	3.8
[4]	Uganda Kampala	3.8
[4]	India Mumbai Marathas	2.5
[4]	Cape Verde Northwestern	2.5
[4]	Czech republic	2.4
[4]	Morocco Nador Metalsa	2.1
[4]	Central Portugal	2.0
[4]	India West Parsis	2.0
[4]	South African Natal Zulu	2.0
[4]	Kenya	1.7
[4]	Tunisia Tunis	1.7
[4]	Guinea Bissau	1.5
[4]	Georgia Tibilisi	1.4
[4]	Zambia Lusaka	1.2
[4]	Italy Bergamo	1.1
[4]	Pakistan Karachi Parsi	1.1
[4]	Oman	0.8
[4]	Sudanese	0.8
[4]	Belgium	0.5
[4]	Southeast France	0.4
[4]	Mongolia Buriat	0.4
[4]	Wales	0.2

HLA A*6602 frequencies

		freq
ref.	Population	(%)
[4]	South African Natal Zulu	1.5
[4]	Cameroon Yaounde	1.1
[4]	Cameroon Bamileke	0.6
[4]	Senegal Niokholo Mandenka	0.5
[4]	Kenya Nandi	0.4
[4]	Zimbabwe Harare Shona	0.2
[4]	Wales	0.03
HLA A*6603 frequencies
		freq
ref.	Population	(%)
[4]	Cameroon Pygmy Baka	10.0
[4]	Cameroon Bakola Pygmy	9.0
[4]	Cameroon Sawa	7.7
[4]	CAR Mbenzele Pygmy	2.8
[4]	Zimbabwe Harare Shona	0.2

References

1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
2. Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
3. Allele Query Form IMGT/HLA - European Bioinformatics Institute
4. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)