GPM6A

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene.[5][6][7]

GPM6A
Identifiers
Aliases	GPM6A, GPM6, M6A, glycoprotein M6A
External IDs	OMIM: 601275 MGI: 107671 HomoloGene: 3864 GeneCards: GPM6A
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q34.2 Start 175,632,934 bp[1] End 176,002,664 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.3 Start 54,954,843 bp[2] End 55,060,871 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium channel activity • GO:0001948 protein binding Cellular component • integral component of membrane • extracellular vesicle • cell projection • membrane • filopodium • cell membrane • dendritic spine • axonal growth cone • axon • neuronal cell body • neuron projection • extracellular exosome • glutamatergic synapse • integral component of presynaptic active zone membrane Biological process • neuron projection morphogenesis • neuron migration • stem cell differentiation • nervous system development • calcium ion transmembrane transport • synapse assembly • positive regulation of filopodium assembly • neural retina development • response to bacterium • neuron projection development • regulation of synapse organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2823	234267
Ensembl	ENSG00000150625	ENSMUSG00000031517
UniProt	P51674	P35802
RefSeq (mRNA)	NM_001261447 NM_001261448 NM_005277 NM_201591 NM_201592	NM_001253754 NM_001253756 NM_153581
RefSeq (protein)	NP_001248376 NP_001248377 NP_005268 NP_963885 NP_963886	NP_001240683 NP_001240685 NP_705809
Location (UCSC)	Chr 4: 175.63 – 176 Mb	Chr 8: 54.95 – 55.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000150625 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031517 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, et al. (May 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
6. Liang YJ, Wu DF, Stumm R, Höllt V, Koch T (July 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Research. 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.
7. "Entrez Gene: GPM6A glycoprotein M6A".

Further reading

• Boks MP, Hoogendoorn M, Jungerius BJ, Bakker SC, Sommer IE, Sinke RJ, et al. (September 2008). "Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (6): 707–11. doi:10.1002/ajmg.b.30667. PMID 18163405. S2CID 30736289.
• DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
• Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, et al. (February 2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". The Journal of Biological Chemistry. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Mukobata S, Hibino T, Sugiyama A, Urano Y, Inatomi A, Kanai Y, et al. (October 2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochemical and Biophysical Research Communications. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID 12359212.
• Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y, Maekawa H (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34". Cytogenetics and Cell Genetics. 74 (1–2): 138–9. doi:10.1159/000134401. PMID 8893821.
• Yan Y, Narayanan V, Lagenaur C (July 1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". The Journal of Comparative Neurology. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID 8807448.