GOPC

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.[5][6][7]

GOPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DC2, 2LOB, 4E34, 4E35, 4JOE, 4JOF, 4JOG, 4JOH, 4JOJ, 4JOK, 4JOP, 4JOR, 4K6Y, 4K72, 4K75, 4K76, 4K78, 4NMO, 4NMP, 4NMQ, 4NMR, 4NMS, 4NMT, 4NMV, 4Q6H, 4Q6S
Identifiers
Aliases	GOPC, CAL, FIG, GOPC1, PIST, dJ94G16.2, golgi-associated PDZ and coiled-coil motif containing, golgi associated PDZ and coiled-coil motif containing
External IDs	OMIM: 606845 MGI: 2149946 HomoloGene: 10695 GeneCards: GOPC
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 117,560,269 bp[1] End 117,602,542 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 52,335,850 bp[2] End 52,382,124 bp[2]
Gene ontology Molecular function • ion channel binding • GO:0001948 protein binding • GO:0005110 frizzled binding • protein C-terminus binding • GO:0005083 GTPase regulator activity • protein homodimerization activity Cellular component • lysosomal membrane • Golgi-associated vesicle membrane • trans-Golgi network transport vesicle • synapse • cell projection • cell junction • Golgi membrane • GO:0097483, GO:0097481 postsynaptic density • postsynaptic membrane • dendrite • membrane • Golgi apparatus • cytoplasm • cell membrane • macromolecular complex Biological process • ER to Golgi vesicle-mediated transport • protein homooligomerization • apical protein localization • protein transport • Golgi to plasma membrane transport • negative regulation of anion channel activity • cytoplasmic sequestering of CFTR protein • negative regulation of protein localization to cell surface • spermatid nucleus differentiation • GO:0048552 regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57120	94221
Ensembl	ENSG00000047932	ENSMUSG00000019861
UniProt	Q9HD26	Q8BH60
RefSeq (mRNA)	NM_020399 NM_001017408	NM_001199272 NM_053187
RefSeq (protein)	NP_001017408 NP_065132	NP_001186201 NP_444417
Location (UCSC)	Chr 6: 117.56 – 117.6 Mb	Chr 10: 52.34 – 52.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM][7]

Interactions

GOPC has been shown to interact with GRID2,[8] BECN1,[8] RHOQ,[5] ACCN3,[9] Cystic fibrosis transmembrane conductance regulator[10][11] and CSPG5.[12]

References

1. GRCh38: Ensembl release 89: ENSG00000047932 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019861 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
6. Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.
7. "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing".
8. Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. United States. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. ISSN 0896-6273. PMID 12372286. S2CID 10534933.
9. Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. United States. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. ISSN 0021-9258. PMID 15317815.
10. Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". J. Biol. Chem. United States. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. ISSN 0021-9258. PMID 11707463.
11. Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (Feb 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. United States. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. ISSN 0021-9258. PMID 12471024.
12. Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. United States. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. ISSN 0021-9258. PMID 12885772.

Further reading

• Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome". EMBO J. 17 (23): 6879–87. doi:10.1093/emboj/17.23.6879. PMC 1171036. PMID 9843494.
• Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6". J. Biol. Chem. 276 (31): 29456–65. doi:10.1074/jbc.M104137200. PMID 11384996.
• Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression". J. Biol. Chem. 277 (5): 3520–9. doi:10.1074/jbc.M110177200. PMID 11707463.
• Yao R, Ito C, Natsume Y, et al. (2002). "Lack of acrosome formation in mice lacking a Golgi protein, GOPC". Proc. Natl. Acad. Sci. U.S.A. 99 (17): 11211–6. Bibcode:2002PNAS...9911211Y. doi:10.1073/pnas.162027899. PMC 123235. PMID 12149515.
• Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.
• Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins". J. Biol. Chem. 278 (8): 6440–9. doi:10.1074/jbc.M211050200. PMID 12471024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. Bibcode:2003PNAS..100..916C. doi:10.1073/pnas.242741799. PMC 298701. PMID 12538861.
• Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer. 37 (1): 58–71. doi:10.1002/gcc.10207. PMID 12661006. S2CID 39776967.
• Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST". J. Biol. Chem. 278 (41): 40136–43. doi:10.1074/jbc.M305577200. PMID 12885772.
• Cheng J, Wang H, Guggino WB (2004). "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL". J. Biol. Chem. 279 (3): 1892–8. doi:10.1074/jbc.M308640200. PMID 14570915.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
• He J, Bellini M, Xu J, et al. (2005). "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression". J. Biol. Chem. 279 (48): 50190–6. doi:10.1074/jbc.M404876200. PMID 15358775.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cheng J, Wang H, Guggino WB (2005). "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10". J. Biol. Chem. 280 (5): 3731–9. doi:10.1074/jbc.M410026200. PMID 15546864.
• Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST". J. Biol. Chem. 280 (32): 28944–51. doi:10.1074/jbc.M504937200. PMID 15951434.