GDP-L-galactose phosphorylase

GDP-L-galactose phosphorylase (EC 2.7.7.69, VTC2, VTC5) is an enzyme with systematic name GDP:alpha-L-galactose 1-phosphate guanylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

GDP-L-galactose + phosphate alpha-L-galactose 1-phosphate + GDP
GDP-L-galactose phosphorylase
Identifiers
EC number2.7.7.69
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme catalyses a reaction of the Smirnoff-Wheeler pathway.

References
  1. Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG (June 2007). "Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants". The Journal of Biological Chemistry. 282 (26): 18879–85. doi:10.1074/jbc.m702094200. PMC 2556065. PMID 17462988.
  2. Linster CL, Adler LN, Webb K, Christensen KC, Brenner C, Clarke SG (July 2008). "A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction". The Journal of Biological Chemistry. 283 (27): 18483–92. doi:10.1074/jbc.m802594200. PMC 2441562. PMID 18463094.
  3. Dowdle J, Ishikawa T, Gatzek S, Rolinski S, Smirnoff N (November 2007). "Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability". The Plant Journal. 52 (4): 673–89. doi:10.1111/j.1365-313x.2007.03266.x. PMID 17877701.
  4. Müller-Moulé P (September 2008). "An expression analysis of the ascorbate biosynthesis enzyme VTC2". Plant Molecular Biology. 68 (1–2): 31–41. doi:10.1007/s11103-008-9350-4. PMID 18516687.
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