GABRQ

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene.[5][6] The protein encoded by this gene is a subunit of the GABAA receptor.

GABRQ
Identifiers
Aliases	GABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit, gamma-aminobutyric acid type A receptor subunit theta
External IDs	OMIM: 300349 MGI: 1888498 HomoloGene: 10233 GeneCards: GABRQ
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 152,637,895 bp[1] End 152,657,542 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 72,825,178 bp[2] End 72,842,602 bp[2]
Gene ontology Molecular function • GABA-A receptor activity • neurotransmitter transporter activity • chloride channel activity • extracellular ligand-gated ion channel activity • ion channel activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • GABA-A receptor complex • postsynaptic membrane • membrane • receptor complex • cell membrane • synapse • integral component of plasma membrane • chloride channel complex • cell junction • neuron projection Biological process • chloride transmembrane transport • ion transport • chloride transport • signal transduction • neurotransmitter transport • ion transmembrane transport • chemical synaptic transmission • regulation of membrane potential • nervous system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55879	57249
Ensembl	ENSG00000268089	ENSMUSG00000031344
UniProt	Q9UN88	Q9JLF1
RefSeq (mRNA)	NM_018558	NM_001290435 NM_020488
RefSeq (protein)	NP_061028	NP_001277364 NP_065234
Location (UCSC)	Chr X: 152.64 – 152.66 Mb	Chr X: 72.83 – 72.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The θ subunit has highest sequence similarity with the β1 subunit.[6] This subunit coassembles with:

• α2, β1, and γ1[6]
• α3 and β1[7]
• α3, β1, and ε.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000268089 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031344 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMID 10804200.
6. Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
7. Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348. PMID 16412217.

Further reading

• Whiting PJ, Bonnert TP, McKernan RM, et al. (1999). "Molecular and functional diversity of the expanding GABA-A receptor gene family". Ann. N. Y. Acad. Sci. 868: 645–653. doi:10.1111/j.1749-6632.1999.tb11341.x. PMID 10414349.
• Craddock N, Jones L, Jones IR, et al. (2010). "Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype". Mol. Psychiatry. 15 (2): 146–153. doi:10.1038/mp.2008.66. PMC 3967096. PMID 19078961.
• Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. doi:10.1523/jneurosci.20-10-03588.2000. PMID 10804200.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053.
• Bonnert TP, McKernan RM, Farrar S, et al. (1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–9896. doi:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fernandez F, Esposito T, Lea RA, et al. (2008). "Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility". BMC Med. Genet. 9: 109. doi:10.1186/1471-2350-9-109. PMC 2615754. PMID 19087248.
• Tabakoff B, Saba L, Printz M, et al. (2009). "Genetical genomic determinants of alcohol consumption in rats and humans". BMC Biol. 7: 70. doi:10.1186/1741-7007-7-70. PMC 2777866. PMID 19874574.

External links

• GABRQ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)