Fellutamide

Fellutamide A and B are tripeptide derivatives from Penicillium fellutanum and other fungi. They are potent proteasome inhibitor that stimulates nerve growth factor synthesis in vitro.[1][2] It strongly inhibits the growth of the tuberculosis-causing bacterium Mycobacterium tuberculosis.[3] Its biosynthetic pathway has been determined in the filamentous fungus Aspergillus nidulans.[4]

Fellutamide A and B

See also

References
  1. Hines J, Groll M, Fahnestock M, Crews CM (May 2008). "Proteasome inhibition by fellutamide B induces nerve growth factor synthesis". Chemistry & Biology. 15 (5): 501–12. doi:10.1016/j.chembiol.2008.03.020. PMC 2485210. PMID 18482702.
  2. Yamaguchi K, Tsuji T, Wakuri S, Yazawa K, Kondo K, Shigemori H, Kobayashi J (February 1993). "Stimulation of nerve growth factor synthesis and secretion by fellutamide A in vitro". Bioscience, Biotechnology, and Biochemistry. 57 (2): 195–9. doi:10.1271/bbb.57.195. PMID 7763492.
  3. Lin G, Li D, Chidawanyika T, Nathan C, Li H (September 2010). "Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome". Archives of Biochemistry and Biophysics. 501 (2): 214–20. doi:10.1016/j.abb.2010.06.009. PMC 2930046. PMID 20558127.
  4. Yeh HH, Ahuja M, Chiang YM, Oakley CE, Moore S, Yoon O, Hajovsky H, Bok JW, Keller NP, Wang CC, Oakley BR (August 2016). "Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor". ACS Chemical Biology. 11 (8): 2275–84. doi:10.1021/acschembio.6b00213. PMC 6457343. PMID 27294372.


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