Elvucitabine

Elvucitabine is an experimental nucleoside reverse transcriptase inhibitor (NRTI), developed by Achillion Pharmaceuticals, Inc. for the treatment of HIV infection.

Elvucitabine

Clinical data
ATC code	none
Identifiers
IUPAC name 4-amino-5-fluoro-1-[(2S,5R)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one
CAS Number	181785-84-2
PubChem CID	469717
ChemSpider	412628
UNII	M09BUF90C0
ChEMBL	ChEMBL38700
NIAID ChemDB	060327
CompTox Dashboard (EPA)	DTXSID20171185
Chemical and physical data
Formula	C9H10FN3O3
Molar mass	227.195 g·mol^−1
3D model (JSmol)	Interactive image
SMILES c1c(c(nc(=O)n1[C@@H]2C=C[C@@H](O2)CO)N)F
InChI InChI=1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m1/s1 Key:HSBKFSPNDWWPSL-VDTYLAMSSA-N
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Elvucitabine belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs).[1] NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction). By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

Elvucitabine is similar in chemical structure to the FDA-approved NRTIs lamivudine (brand name Epivir) and emtricitabine (brand name Emtriva). However, in vitro studies have suggested that elvucitabine may work on certain HIV strains against which other NRTIs, such as lamivudine and emtricitabine, no longer work. (In vitro studies are studies done in test tubes or other laboratory equipment and not on animals or humans).

Studies have also suggested that elvucitabine may be effective against hepatitis B virus (HBV).[2]

Currently, it is in Phase II clinical trials.[3]

References

1. "Archived copy". Archived from the original on 2014-11-29. Retrieved 2014-11-22.CS1 maint: archived copy as title (link)
3. "Elvucitabine". AIDSmeds.com. November 5, 2007. Archived from the original on March 21, 2008. Retrieved March 21, 2008.