Deoxyguanosine kinase

In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction

ATP + deoxyguanosine ADP + dGMP
deoxyguanosine kinase
Identifiers
EC number2.7.1.113
CAS number39471-28-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyguanosine 5'-phosphotransferase. Other names in common use include deoxyguanosine kinase (phosphorylating), (dihydroxypropoxymethyl)guanine kinase, 2'-deoxyguanosine kinase, and NTP-deoxyguanosine 5'-phosphotransferase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2JAQ, 2JAS, 2JAT, and 2OCP.

Clinical

Mutations in this gene have been linked to inherited mitochondrial DNA depletion syndromes, neonatal liver failure, nystagmus and hypotonia.

References

    • Barker J, Lewis RA (1981). "Deoxyguanosine kinase of neonatal mouse skin tissue". Biochim. Biophys. Acta. 658 (1): 111–23. doi:10.1016/0005-2744(81)90254-0. PMID 6260206.
    • Gower Jr WR, Carr MC, Ives DH (1979). "Deoxyguanosine kinase. Distinct molecular forms in mitochondria and cytosol". J. Biol. Chem. 254 (7): 2180–3. PMID 218928.


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