Cortisol sulfotransferase
In enzymology, a cortisol sulfotransferase (EC 2.8.2.18) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + cortisol adenosine 3',5'-bisphosphate + cortisol 21-sulfate
| cortisol sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.18 | ||||||||
| CAS number | 71427-08-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and cortisol, whereas its two products are adenosine 3',5'-bisphosphate and cortisol 21-sulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase. Other names in common use include glucocorticosteroid sulfotransferase, and glucocorticoid sulfotransferase.
References
- Singer SS, Brill B (1982). "Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol". Biochim. Biophys. Acta. 712 (3): 590–6. doi:10.1016/0005-2760(82)90287-9. PMID 6957246.
- Singer SS, Giera D, Johnson J, Sylvester S (1976). "Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations". Endocrinology. 98 (4): 963–74. doi:10.1210/endo-98-4-963. PMID 1278101.
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