Collagen, type XXV, alpha 1

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.[5][6]

COL25A1
Identifiers
Aliases	COL25A1, AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chain
External IDs	OMIM: 610004 MGI: 1924268 HomoloGene: 57111 GeneCards: COL25A1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 108,808,725 bp[1] End 109,302,752 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 130,131,501 bp[2] End 130,599,877 bp[2]
Gene ontology Molecular function • heparin binding • amyloid-beta binding • extracellular matrix structural constituent • extracellular matrix structural constituent conferring tensile strength Cellular component • integral component of membrane • extracellular region • cell membrane • collagen • endoplasmic reticulum lumen • membrane • extracellular • integral component of plasma membrane • extracellular matrix • collagen-containing extracellular matrix Biological process • axonogenesis involved in innervation • extracellular matrix organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84570	77018
Ensembl	ENSG00000188517	ENSMUSG00000058897
UniProt	Q9BXS0	Q99MQ5
RefSeq (mRNA)	NM_001256074 NM_032518 NM_198721	NM_001244952 NM_029838 NM_198711
RefSeq (protein)	NP_001243003 NP_115907 NP_942014	NP_001231881 NP_084114 NP_942004
Location (UCSC)	Chr 4: 108.81 – 109.3 Mb	Chr 3: 130.13 – 130.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM][6]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000188517 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058897 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537.
6. "Entrez Gene: COL25A1 collagen, type XXV, alpha 1".

Further reading

• Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation". Biochemistry. 44 (47): 15602–9. doi:10.1021/bi051263e. PMID 16300410.
• Söderberg L, Dahlqvist C, Kakuyama H, et al. (2005). "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates". FEBS J. 272 (9): 2231–6. doi:10.1111/j.1742-4658.2005.04647.x. hdl:10616/39314. PMID 15853808. S2CID 26505595.
• Osada Y, Hashimoto T, Nishimura A, et al. (2005). "CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils". J. Biol. Chem. 280 (9): 8596–605. doi:10.1074/jbc.M413340200. PMID 15615705.
• Söderberg L, Kakuyama H, Möller A, et al. (2005). "Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site". J. Biol. Chem. 280 (2): 1007–15. doi:10.1074/jbc.M403628200. PMID 15522881.
• Kowa H, Sakakura T, Matsuura Y, et al. (2004). "Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits". Am. J. Pathol. 165 (1): 273–81. doi:10.1016/s0002-9440(10)63295-6. PMC 1618534. PMID 15215182.
• Söderberg L, Zhukareva V, Bogdanovic N, et al. (2004). "Molecular identification of AMY, an Alzheimer disease amyloid-associated protein". J. Neuropathol. Exp. Neurol. 62 (11): 1108–17. doi:10.1093/jnen/62.11.1108. PMID 14656069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.