Climbazole

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.[2] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Climbazole

Clinical data
Routes of administration	topical
ATC code	none
Identifiers
IUPAC name (RS)-1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one[1]
CAS Number	38083-17-9
PubChem CID	37907
ChemSpider	34752
UNII	9N42CW7I54
ChEBI	CHEBI:83499
ChEMBL	ChEMBL1437764
CompTox Dashboard (EPA)	DTXSID6046555
ECHA InfoCard	100.048.870
Chemical and physical data
Formula	C15H17ClN2O2
Molar mass	292.76 g·mol^−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES CC(C)(C)C(=O)C(n1ccnc1)Oc2ccc(cc2)Cl
InChI InChI=1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 Key:OWEGWHBOCFMBLP-UHFFFAOYSA-N
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Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

References

1. Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine
2. Wigger-Alberti W, Kluge K, Elsner P (August 2001). "[Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]". Praxis. 90 (33): 1346–9. PMID 11534318.