CRLF2

Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).[5][6][7]

CRLF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NN5, 4NN6, 4NN7
Identifiers
Aliases	CRLF2, CRL2, CRLF2Y, TSLPR, cytokine receptor-like factor 2, cytokine receptor like factor 2
External IDs	OMIM: 300357, 400023 MGI: 1889506 HomoloGene: 49476 GeneCards: CRLF2
Gene location (Human) Chr. X chromosome (human)[1] Band X;Y Start 1,187,549 bp[1] End 1,212,723 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 109,554,709 bp[2] End 109,558,993 bp[2]
Gene ontology Molecular function • cytokine receptor activity • cytokine binding Cellular component • membrane • integral component of membrane • extracellular region • cell membrane • external side of plasma membrane • receptor complex Biological process • interleukin-7-mediated signaling pathway • positive regulation of cell proliferation • cytokine-mediated signaling pathway • positive regulation of mast cell activation • positive regulation of STAT cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64109	57914
Ensembl	ENSG00000205755	ENSMUSG00000033467
UniProt	Q9HC73	Q8CII9
RefSeq (mRNA)	NM_001012288 NM_022148	NM_001164735 NM_016715 NM_001310694
RefSeq (protein)	NP_001012288 NP_071431	NP_001158207 NP_001297623 NP_057924
Location (UCSC)	Chr X: 1.19 – 1.21 Mb	Chr 5: 109.55 – 109.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000205755 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033467 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X (Mar 2001). "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes". Biochem Biophys Res Commun. 281 (4): 878–83. doi:10.1006/bbrc.2001.4432. PMID 11237741.
6. Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001). "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR". Cytogenet Cell Genet. 93 (1–2): 23–5. doi:10.1159/000056941. PMID 11474172.
7. "Entrez Gene: CRLF2 cytokine receptor-like factor 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hiroyama T, Iwama A, Morita Y, et al. (2000). "Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells". Biochem. Biophys. Res. Commun. 272 (1): 224–9. doi:10.1006/bbrc.2000.2764. PMID 10872831. S2CID 38299268.
• Reche PA, Soumelis V, Gorman DM, et al. (2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". J. Immunol. 167 (1): 336–43. doi:10.4049/jimmunol.167.1.336. PMID 11418668.
• Blagoev B, Nielsen MM, Angrist M, et al. (2002). "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene". Gene. 284 (1–2): 161–8. doi:10.1016/S0378-1119(02)00380-3. PMID 11891057.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rochman I, Watanabe N, Arima K, et al. (2007). "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells". J. Immunol. 178 (11): 6720–4. doi:10.4049/jimmunol.178.11.6720. PMID 17513717.

External links

• Human CRLF2 genome location and CRLF2 gene details page in the UCSC Genome Browser.