CHTF18

Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.[5][6]

CHTF18
Identifiers
Aliases	CHTF18, C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, chromosome transmission fidelity factor 18
External IDs	OMIM: 613201 MGI: 2384887 HomoloGene: 32532 GeneCards: CHTF18
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 788,046 bp[1] End 800,737 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,718,926 bp[2] End 25,727,419 bp[2]
Gene ontology Molecular function • nucleotide binding • DNA binding • GO:0043142 single-stranded DNA helicase activity • GO:0001948 protein binding • ATP binding • DNA clamp loader activity Cellular component • membrane • Ctf18 RFC-like complex • cell nucleus • nucleoplasm • cytosol Biological process • DNA replication • cell cycle • positive regulation of DNA-directed DNA polymerase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63922	214901
Ensembl	ENSG00000127586	ENSMUSG00000019214
UniProt	Q8WVB6	Q8BIW9
RefSeq (mRNA)	NM_022092	NM_145409
RefSeq (protein)	NP_071375	NP_663384
Location (UCSC)	Chr 16: 0.79 – 0.8 Mb	Chr 17: 25.72 – 25.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

CHTF18 has been shown to interact with:

• DCC1,[7][8]
• PCNA,[5]
• RFC2,[7][8]
• RFC3,[7][8]
• RFC4,[7] and
• RFC5.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000127586 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019214 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
6. "Entrez Gene: CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)".
7. Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
8. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.

External links

• Human CHTF18 genome location and CHTF18 gene details page in the UCSC Genome Browser.

Further reading

• Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T (Jul 2007). "A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity". The Journal of Biological Chemistry. 282 (29): 20906–14. doi:10.1074/jbc.M610102200. PMID 17545166.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
• Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
• Naiki T, Kondo T, Nakada D, Matsumoto K, Sugimoto K (Sep 2001). "Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway". Molecular and Cellular Biology. 21 (17): 5838–45. doi:10.1128/MCB.21.17.5838-5845.2001. PMC 87303. PMID 11486023.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (Feb 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.