CEP135

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.[5][6][7] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.[8] CEP135 is required for the centriolar localization of CEP250.[9]

CEP135
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FCN
Identifiers
Aliases	CEP135, CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDs	OMIM: 611423 MGI: 2681869 HomoloGene: 45709 GeneCards: CEP135
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 55,948,871 bp[1] End 56,033,361 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 76,588,698 bp[2] End 76,646,466 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein C-terminus binding • GO:0001948 protein binding Cellular component • cytoplasm • centriole • cytosol • centrosome • cytoskeleton Biological process • centriole replication • centriole-centriole cohesion • G2/M transition of mitotic cell cycle • positive regulation of non-motile cilium assembly • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • positive regulation of establishment of protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9662	381644
Ensembl	ENSG00000174799	ENSMUSG00000036403
UniProt	Q66GS9	Q6P5D4
RefSeq (mRNA)	NM_014645 NM_025009	NM_199032
RefSeq (protein)	NP_079285	NP_950197
Location (UCSC)	Chr 4: 55.95 – 56.03 Mb	Chr 5: 76.59 – 76.65 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000174799 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036403 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
7. "Entrez Gene: CEP135 centrosomal protein 135kDa".
8. Ohta T, Essner R, Ryu JH, Palazzo RE, Uetake Y, Kuriyama R (January 2002). "Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells". J. Cell Biol. 156 (1): 87–99. doi:10.1083/jcb.200108088. PMC 2173569. PMID 11781336.
9. Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.

External links

• Human CEP135 genome location and CEP135 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 135 kDa

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.