CDK5RAP1

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.[5][6][7][8]

CDK5RAP1
Identifiers
Aliases	CDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1
External IDs	OMIM: 608200 MGI: 1914221 HomoloGene: 9502 GeneCards: CDK5RAP1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 33,358,839 bp[1] End 33,401,561 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 154,335,380 bp[2] End 154,373,010 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0032403 macromolecular complex binding • transferase activity • iron-sulfur cluster binding • catalytic activity • protein kinase binding • metal ion binding • N6-isopentenyladenosine methylthiotransferase activity • 4 iron, 4 sulfur cluster binding Cellular component • cytoplasm • mitochondrion • cellular component Biological process • regulation of neuron differentiation • brain development • regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of cyclin-dependent protein serine/threonine kinase activity • tRNA modification • positive regulation of mitochondrial translation • mitochondrial tRNA modification • positive regulation of translational fidelity • tRNA methylthiolation • GO:0016547 RNA modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51654	66971
Ensembl	ENSG00000101391	ENSMUSG00000027487
UniProt	Q96SZ6	Q8BTW8
RefSeq (mRNA)	NM_001278167 NM_001278168 NM_001278169 NM_016082 NM_016408 NM_001365728	NM_025876
RefSeq (protein)	NP_001265096 NP_001265097 NP_001265098 NP_057166 NP_057492 NP_001352657	NP_080152
Location (UCSC)	Chr 20: 33.36 – 33.4 Mb	Chr 2: 154.34 – 154.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000101391 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027487 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
6. Ching YP, Pang AS, Lam WH, Qi RZ, Wang JH (Apr 2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J Biol Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
7. Zou X, Ji C, Jin F, Liu J, Wu M, Zheng H, Wang Y, Li X, Xu J, Gu S, Xie Y, Mao Y (Aug 2004). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1". Genes Genet Syst. 79 (3): 177–82. doi:10.1266/ggs.79.177. PMID 15329498.
8. "Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1".

External links

• Human CDK5RAP1 genome location and CDK5RAP1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.