CCR10

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.[5][6]

CCR10
Identifiers
Aliases	CCR10, GPR2, C-C motif chemokine receptor 10
External IDs	OMIM: 600240 MGI: 1096320 HomoloGene: 7271 GeneCards: CCR10
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,678,889 bp[1] End 42,683,917 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 64.34 cM Start 101,172,997 bp[2] End 101,175,443 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • C-C chemokine receptor activity • G-protein coupled receptor activity • chemokine receptor activity • signal transducer activity • GO:0001948 protein binding • chemokine binding • C-C chemokine binding Cellular component • cell surface • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • endoplasmic reticulum • external side of plasma membrane Biological process • positive regulation of cytosolic calcium ion concentration • chemotaxis • chemokine-mediated signaling pathway • G-protein coupled receptor signaling pathway • immune response • signal transduction • calcium-mediated signaling • cell chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2826	12777
Ensembl	ENSG00000184451	ENSMUSG00000044052
UniProt	P46092	Q9JL21
RefSeq (mRNA)	NM_016602	NM_007721
RefSeq (protein)	NP_057686	NP_031747
Location (UCSC)	Chr 17: 42.68 – 42.68 Mb	Chr 11: 101.17 – 101.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.[6]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.[7] This receptor is normally expressed by melanocytes,[8] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,[9] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000184451 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044052 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
6. "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".
7. Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer. 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479. S2CID 205467365.
8. Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
9. Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.
10. Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936.
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696.
• Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
• Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587.
• Pan J, Kunkel EJ, Gosslar U, et al. (2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". J. Immunol. 165 (6): 2943–9. doi:10.4049/jimmunol.165.6.2943. PMID 10975800.
• Patel L, Charlton SJ, Chambers JK, Macphee CH (2001). "Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations". Cytokine. 14 (1): 27–36. doi:10.1006/cyto.2000.0851. PMID 11298490.
• Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Notohamiprodjo M, Segerer S, Huss R, et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer. 115 (4): 641–7. doi:10.1002/ijc.20922. PMID 15700309. S2CID 45425929.
• Rodrigues-Lisoni FC, Mehet DK, Mehemet DK, et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. hdl:11449/21716. PMID 16460738. S2CID 11454792.
• Fujita Y, Abe R, Sasaki M, et al. (2006). "Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides". Clin. Cancer Res. 12 (9): 2670–5. doi:10.1158/1078-0432.CCR-05-1513. PMID 16675558.
• Eksteen B, Miles A, Curbishley SM, et al. (2006). "Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10". J. Immunol. 177 (1): 593–603. doi:10.4049/jimmunol.177.1.593. PMID 16785557.
• Harasawa H, Yamada Y, Hieshima K, et al. (2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma". Leuk. Lymphoma. 47 (10): 2163–73. doi:10.1080/10428190600775599. PMID 17071491. S2CID 32495340.

External links

• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
• "Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.