Biotin—(acetyl-CoA-carboxylase) ligase

In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15) is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]
biotin-[acetyl-CoA-carboxylase] ligase
Identifiers
EC number6.3.4.15
CAS number37340-95-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.

This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.[1]

Nomenclature

The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include:

  • biotin-[acetyl-CoA carboxylase] synthetase,
  • biotin-[acetyl coenzyme A carboxylase] synthetase,
  • acetyl coenzyme A holocarboxylase synthetase,
  • acetyl CoA holocarboxylase synthetase,
  • biotin:apocarboxylase ligase,
  • biotin holoenzyme synthetase,
  • and HCS.

References
  1. Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo-oligomers and the control of protein function". Arch. Biochem. Biophys. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.

Further reading


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