BMP2K

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[5]

BMP2K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4W9W, 4W9X, 5I3R, 5I3O, 5IKW
Identifiers
Aliases	BMP2K, BIKE, HRIHFB2017, BMP2 inducible kinase
External IDs	OMIM: 617648 MGI: 2155456 HomoloGene: 34134 GeneCards: BMP2K
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.21 Start 78,776,342 bp[1] End 78,916,372 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E3 Start 96,997,689 bp[2] End 97,091,867 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase activity • transferase activity • nucleotide binding • protein kinase activity • ATP binding • protein serine/threonine kinase activity • phosphatase regulator activity • AP-2 adaptor complex binding Cellular component • nuclear speck • cell nucleus • cytoplasm Biological process • GO:0048552 regulation of catalytic activity • phosphorylation • regulation of bone mineralization • protein phosphorylation • positive regulation of Notch signaling pathway • regulation of clathrin-dependent endocytosis • regulation of endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55589	140780
Ensembl	ENSG00000138756	ENSMUSG00000034663
UniProt	Q9NSY1	Q91Z96
RefSeq (mRNA)	NM_017593 NM_198892	NM_080708
RefSeq (protein)	NP_060063 NP_942595	NP_542439
Location (UCSC)	Chr 4: 78.78 – 78.92 Mb	Chr 5: 97 – 97.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000138756 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034663 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BMP2K BMP2 inducible kinase".

External links

• Human BMP2K genome location and BMP2K gene details page in the UCSC Genome Browser.

Further reading

• Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression. 11 (1–3): 23–45. PMID 11693963.
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
• Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry. 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology. 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968. S2CID 28129401.
• Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research. 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015. S2CID 25680897.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.