Alkylglycerophosphoethanolamine phosphodiesterase

In enzymology, an alkylglycerophosphoethanolamine phosphodiesterase (EC 3.1.4.39) is an enzyme that catalyzes the chemical reaction

1-alkyl-sn-glycero-3-phosphoethanolamine + H2O 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
alkylglycerophosphoethanolamine phosphodiesterase
Identifiers
EC number3.1.4.39
CAS number62213-15-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 1-alkyl-sn-glycero-3-phosphoethanolamine and H2O, whereas its two products are 1-alkyl-sn-glycerol 3-phosphate and ethanolamine.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase. This enzyme is also called lysophospholipase D. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FJ2.

References

    • Wykle RL, Schremmer JM (1974). "A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes". J. Biol. Chem. 249 (6): 1742–6. PMID 4855486.


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