ACYP1

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.[5][6][7]

ACYP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K7J, 2K7K, 2VH7, 2W4C, 2W4P, 3TOQ
Identifiers
Aliases	ACYP1, ACYPE, acylphosphatase 1
External IDs	OMIM: 600875 MGI: 1913454 HomoloGene: 11932 GeneCards: ACYP1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 75,053,237 bp[1] End 75,069,483 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 85,272,398 bp[2] End 85,288,438 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • hydrolase activity • acylphosphatase activity Cellular component • extracellular exosome Biological process • phosphate-containing compound metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	97	66204
Ensembl	ENSG00000119640	ENSMUSG00000008822
UniProt	P07311	P56376
RefSeq (mRNA)	NM_001107 NM_001302616 NM_001302617 NM_203488	NM_025421 NM_001364360 NM_001364361
RefSeq (protein)	NP_001098 NP_001289545 NP_001289546	NP_079697 NP_001351289 NP_001351290
Location (UCSC)	Chr 14: 75.05 – 75.07 Mb	Chr 12: 85.27 – 85.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000119640 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008822 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. doi:10.1016/0014-5793(95)00553-L. PMID 7796909.
6. Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. doi:10.1159/000015037. PMID 9730610.
7. "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type".

External links

• Human ACYP1 genome location and ACYP1 gene details page in the UCSC Genome Browser.

Further reading

• Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. PMID 1645713.
• Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. PMID 2169259.
• Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. doi:10.1021/bi00372a044. PMID 3026468.
• Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase" (PDF). The Journal of Biological Chemistry. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302.
• Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. doi:10.1080/15216540310001654349. PMID 14992377.