(hydroxymethylglutaryl-CoA reductase (NADPH))-phosphatase
In enzymology, a [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC 3.1.3.47) is an enzyme that catalyzes the chemical reaction
- [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate
| [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.47 | ||||||||
| CAS number | 73507-97-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are hydroxymethylglutaryl-CoA reductase (NADPH) phosphate and H2O, whereas its two products are hydroxymethylglutaryl-CoA reductase (NADPH) and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.
References
- Gil G, Hegardt FG (1982). "Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver". Arch. Biochem. Biophys. 214 (1): 192–8. doi:10.1016/0003-9861(82)90022-4. PMID 6282220.
- Gil G, Sitges M, Hegardt FG (1981). "Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases". Biochim. Biophys. Acta. 663 (1): 211–21. doi:10.1016/0005-2760(81)90207-1. PMID 6260210.
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