(deoxy)nucleoside-phosphate kinase
In enzymology, a (deoxy)nucleoside-phosphate kinase (EC 2.7.4.13) is an enzyme that catalyzes the chemical reaction
- ATP + deoxynucleoside phosphate ADP + deoxynucleoside diphosphate
| (deoxy)nucleoside-phosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.4.13 | ||||||||
| CAS number | 37278-20-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1DEK and 1DEL.
References
- BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5". J. Biol. Chem. 240: 439–45. PMID 14253449.