Zn2+-exporting ATPase

In enzymology, a Zn2+-exporting ATPase (EC 3.6.3.5) is an enzyme that catalyzes the chemical reaction

ATP + H2O + Zn2+in ADP + phosphate + Zn2+out
zinc-exporting ATPase
Identifiers
EC number3.6.3.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are ATP, H2O, and Zn2+, whereas its 3 products are ADP, phosphate, and Zn2+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (Zn2+-exporting). Other names in common use include Zn(II)-translocating P-type ATPase, P1B-type ATPase, and AtHMA4 (the A. thaliana protein).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1MWY and 1MWZ. Moreover, nanobodies have recently been raised against a zinc-transporting ATPase (ZntA) which are able to bind and inhibit the ATPase activity, showing potential for further structural studies.[1]

References

  1. Longhin, Elena; Grønberg, Christina; Hu, Qiaoxia; Duelli, Annette; Andersen, Kasper; Laursen, Nick; Gourdon, Pontus (7 November 2018). "Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase". Antibodies. 7 (4): 39. doi:10.3390/antib7040039. PMC 6698960. PMID 31544889.


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