XJB-5-131

XJB-5-131 is a synthetic antioxidant. In a mouse model of Huntington's disease, it has been shown to reduce oxidative damage to mitochondrial DNA, and to maintain mitochondrial DNA copy number.[1] XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death.[2]

XJB-5-131
Legal status
Legal status
  • experimental
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC53H80N7O9
Molar mass959.26 g·mol−1
3D model (JSmol)

References

  1. Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, et al. (November 2012). "Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease". Cell Reports. 2 (5): 1137–42. doi:10.1016/j.celrep.2012.10.001. PMC 3513647. PMID 23122961.
  2. Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P (September 2016). "A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis". ACS Central Science. 2 (9): 653–659. doi:10.1021/acscentsci.6b00199. PMC 5043442. PMID 27725964.
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