WDR45L

WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene.[5]

WDR45B
Identifiers
Aliases	WDR45B, WDR45L, WIPI-3, WIPI3, WD repeat domain 45B, NEDSBAS
External IDs	OMIM: 609226 MGI: 1914090 HomoloGene: 6028 GeneCards: WDR45B
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,614,562 bp[1] End 82,648,553 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 85.24 cM Start 121,327,224 bp[2] End 121,354,445 bp[2]
Gene ontology Molecular function • phosphatidylinositol-3-phosphate binding • phosphatidylinositol-3,5-bisphosphate binding • GO:0001948 protein binding • TSC1-TSC2 complex binding • lipid binding Cellular component • cytosol • extrinsic component of membrane • pre-autophagosomal structure membrane • pre-autophagosomal structure • lysosome Biological process • protein lipidation • protein localization to pre-autophagosomal structure • mitophagy • autophagy of nucleus • autophagosome assembly • cellular response to starvation • autophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56270	66840
Ensembl	ENSG00000141580	ENSMUSG00000025173
UniProt	Q5MNZ6	Q9CR39
RefSeq (mRNA)	NM_019613	NM_025793
RefSeq (protein)	NP_062559	NP_080069
Location (UCSC)	Chr 17: 82.61 – 82.65 Mb	Chr 11: 121.33 – 121.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Structure and function

WIPI-3 is a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein–protein interactions, and a conserved motif for interaction with phospholipids.[5]

See also

• WIPI protein family

References

1. GRCh38: Ensembl release 89: ENSG00000141580 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025173 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: WDR45-like".

Further reading

• Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Jeffries TR, Dove SK, Michell RH, Parker PJ (2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
• Proikas-Cezanne T, Waddell S, Gaugel A, et al. (2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.