Vy Maria Dong

Vy Maria Dong (born 1976) is a Professor of Chemistry at the University of California, Irvine. She works on enantioselective catalysis and natural product synthesis.[1] She won the American Chemical Society's 2019 Elias James Corey Award.[2]

Vy Dong
Born
Vy Maria Dong

1976 (age 44–45)
Big Spring, Texas
Alma materUniversity of California, Irvine
California Institute of Technology
University of California, Berkeley
AwardsACS Elias J. Corey Award, Outstanding Original Contribution in Organic Synthesis by a Young Investigator (2019)

Agnes Fay Morgan Research Award, Iota Sigma PI, (2016)

The Society of Synthetic Organic Chemistry, Japan, Lectureship (2013)

Japan Society for the Promotion of Science Fellowship (2013)

Novartis Chemistry Lecturer (2012-2013)

Eli Lilly Grantee Award (2011-2012)

Roche Excellence Award in Chemistry (2011)

Adrian Brook Distinguished Professor (2011)

Early Researcher Award (2010)

Amgen Young Investigator (2010)

Arthur C. Cope Scholar Award (2010)

AstraZeneca Award in Chemistry (2010-2012)

Alfred P. Sloan Research Fellowship (2009-2011)

Inaugural Eli Lilly Young Investigator Lecturer at the University of Wisconsin-Madison (2009)

CNC-IUPAC Travel Award (2009)

Boehringer Ingelheim (Canada) Young Investigator Award for Organic Chemistry (2008-2011)

Ontario Research Fund (2008-2011)

Connaught New Staff Matching Grant (2007)

Merck Frosst Young Investigator Award (2007)

Thieme Synlett/Synthesis Journal Award (2007)

Ruth L. Kirschstein National Institutes of Health Postdoctoral Fellowship (2004-06)

National Science Foundation Graduate Research Fellowship (1999-2003)

Anna Louise Hoffman Award for Graduate Research from Iota Sigma Pi (2002)

American Chemical Society Poster Award Winner, Pacifichem ACS Conference (2000)

Don L. Bunker Honor’s Thesis Prize, UC Irvine, (1998)

Chancellor’s Award for Excellence in Undergraduate Research, UC Irvine (1998)

Phi Beta Kappa (1998)

Pfizer Organic Chemistry Fellowship (1997)

Brookhaven National Lab Nuclear and Radiochemistry Fellowship (1997)
Scientific career
FieldsChemistry
InstitutionsUniversity of Toronto
University of California, Irvine
ThesisNovel Variants of the Zwitterionic Claisen Rearrangement and the Total Synthesis of Erythronolide B (2003)
Doctoral advisorDavid MacMillan
Websitewww.chem.uci.edu/~dongv

Early life and education

Dong was born in Big Spring, Texas.[1] She was the daughter of a machinist and manicurist and the first of her family to graduate from college.[3] She grew up in Anaheim, California.[4] She studied chemistry at University of California, Irvine as a Regents' scholar.[3] She decided to become a scientist during her sophomore year after taking a class with Larry E. Overman.[5] She completed a research project with Larry E. Overman, and graduated magna cum laude in 1998.[6] She met her future husband, Wilmer Alkhas, at the University of California, Irvine.[3] She moved to University of California, Berkeley as a graduate student. She worked with David MacMillan and earned her master's degree in 2000. She joined California Institute of Technology for her PhD, working on the Zwitterionic Claisen Rearrangement and the total synthesis of Erythronolide B.[7] Dong was appointed a National Institutes of Health postdoctoral fellow at UC Berkeley College of Chemistry, working on supramolecular chemistry with Robert G. Bergman and Ken Raymond.[8]

Research and career

Dong moved to Canada to work at the University of Toronto. She was awarded an Ontario Research Fund grant in 2008. She delivered the inaugural Eli Lilly Young lecture at the University of Wisconsin–Madison in 2009, where she discussed the catalytic transformations of C-H bonds.[9] At Toronto, she worked on heterocycles for medicinal chemistry. She demonstrated how lactones could be made from ketoaldehydes using rhodium catalysts, achieving regio- and enantioselective lactones without any waste products.[9] She continues to explore new reagents, catalysts and strategies for organic synthesis.[4]

She was awarded an Alfred P. Sloan Foundation Fellowship in 2009 and an Amgen Young Investigator in 2010. In 2010 she was awarded the AstraZeneca Award in Chemistry.[10] She won an Arthur C. Cope Scholar Award of the American Chemical Society in 2010 for her contributions to organic chemistry.[9]

She was made an Adrain Brook distinguished professor at the University of Toronto in 2011.[11] That year she won the Roche Excellence in Chemistry award.[12][11] She was made a Novartis lecturer in 2012 and a Fellow of the Japan Society for the Promotion of Science in 2013.[1] She became a lecturer for the Society of Synthetic Organic Chemistry in Japan.[13] She returned to the University of California, Irvine, in 2013.[14] Her group came with her, working on catalytic hydroacylation and the activation of aldehyde C-H bonds.[15][16] She became an associate editor of the Royal Society of Chemistry journal Chemical Science in 2015.[17] She delivered a talk at TEDxIrvine in 2015, talking about her passion for organic chemistry.[18] She demonstrated that rhodium catalysis could be used to make cyclic peptides.[19][20] She achieved this by using entirely achiral building blocks and hydrogenation catalysts.[19] Rh-hydride catalysis permits enantioselective reduction and allows access to motifs popular in medicinal chemistry.[21] She combines rhodium with Jacobsen's amine.[22]

Awards and honors

In 2016 she was awarded the Iota Sigma Pi Agnes Fay Morgan Research Award for her exceptional research in catalytic hydroacylation in 2016.[23][6] In September 2018 it was announced that Dong was the American Chemical Society Elias James Corey Award winner for 2019.[24][2]

References
  1. Dong, Phi. "The Dong Research Group - About Professor Vy M. Dong". chem.uci.edu. Retrieved 2018-11-04.
  2. "2019 National Award Recipients - American Chemical Society". American Chemical Society. Retrieved 2018-11-04.
  3. "UCI Magazine Fall 2018 -- The American Dream". Issuu. Retrieved 2018-11-04.
  4. "Vy M. Dong | ps.uci.edu". ps.uci.edu. Retrieved 2018-11-04.
  5. "Face to Face with Vy M. Dong". iciq.org. Retrieved 2018-11-04.
  6. "2016 Agnes Fay Morgan Research Award" (PDF). IOTA Sigma Pi. Retrieved 2018-11-04.
  7. Maria, Dong, Vy (2004). "Novel Variants of the Zwitterionic Claisen Rearrangement and the Total Synthesis of Erythronolide B". thesis.library.caltech.edu. Retrieved 2018-11-04.
  8. "Vy Dong | UCI Stories". ucistories.lib.uci.edu. Retrieved 2018-11-04.
  9. "Eli Lilly Young Investigator Lecture - Professor Vy Dong | UW-Madison Department of Chemistry". chem.wisc.edu. Retrieved 2018-11-04.
  10. Anon (2011). "Franco-Spanish Prize: C. Nájera / ACS Pure Chemistry Award: M. S. Sanford / AstraZeneca Award in Chemistry: V. M. Dong". Angewandte Chemie International Edition. 50 (4): 801. doi:10.1002/anie.201006893. ISSN 1433-7851.
  11. "Awards & Distinctions". chem.utoronto.ca. Retrieved 2018-11-04.
  12. Roche. "Roche Symposium Showcases Accomplishments of Next Generation of Chemists". prnewswire.com. Retrieved 2018-11-04.
  13. "Faculty Awards | UCI Department of Chemistry". chem.uci.edu. Retrieved 2018-11-04.
  14. "Vy M. Dong". 化学空间 Chem-Station. 2015-06-02. Retrieved 2018-11-04.
  15. "Never shut down another person's ideas". Chemistry World. Retrieved 2018-11-04.
  16. Murphy, Stephen K.; Bruch, Achim; Dong, Vy M. (2014). "Substrate-Directed Hydroacylation: Rhodium-Catalyzed Coupling of Vinylphenols and Nonchelating Aldehydes". Angewandte Chemie International Edition. 53 (9): 2455–2459. doi:10.1002/anie.201309987. ISSN 1433-7851. PMC 4140243. PMID 24478146.
  17. "Chemical Science welcomes Vy Dong as Associate Editor – Chemical Science Blog". blogs.rsc.org. Retrieved 2018-11-04.
  18. TEDx Talks (2015-07-06), CHON: An Organic Love Story | Vy Dong | TEDxUCIrvine, retrieved 2018-11-04
  19. "Round-the-ring catalysis makes cyclic peptides chiral". Chemistry World. Retrieved 2018-11-04.
  20. Le, Diane N.; Hansen, Eric; Khan, Hasan A.; Kim, Byoungmoo; Wiest, Olaf; Dong, Vy M. (2018). "Hydrogenation catalyst generates cyclic peptide stereocentres in sequence". Nature Chemistry. 10 (9): 968–973. Bibcode:2018NatCh..10..968L. doi:10.1038/s41557-018-0089-5. ISSN 1755-4330. PMC 6824594. PMID 30061616.
  21. Chen, Zhiwei; Dong, Vy M. (2017). "Enantioselective semireduction of allenes". Nature Communications. 8 (1): 784. Bibcode:2017NatCo...8..784C. doi:10.1038/s41467-017-00793-0. ISSN 2041-1723. PMC 5627242. PMID 28978908.
  22. Cruz, Faben A.; Dong, Vy M. (2017). "Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine". Journal of the American Chemical Society. 139 (3): 1029–1032. doi:10.1021/jacs.6b10680. ISSN 0002-7863. PMID 28074655.
  23. "Awards for Professionals". iotasigmapi.info. Retrieved 2018-11-04.
  24. "Professor Vy Dong to receive the 2019 ACS E.J. Corey Award | UCI Department of Chemistry". chem.uci.edu. Retrieved 2018-11-04.
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