USF2

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[5][6]

USF2
Identifiers
Aliases	USF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
External IDs	OMIM: 600390 MGI: 99961 HomoloGene: 2527 GeneCards: USF2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,268,962 bp[1] End 35,279,821 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 19.27 cM Start 30,945,248 bp[2] End 30,956,803 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • protein dimerization activity • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • bHLH transcription factor binding • GO:0001948 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular membrane-bounded organelle • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter by glucose • regulation of transcription from RNA polymerase II promoter • late viral transcription • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter by glucose • lipid homeostasis • lactation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7392	22282
Ensembl	ENSG00000105698	ENSMUSG00000058239
UniProt	Q15853	Q64705
RefSeq (mRNA)	NM_003367 NM_207291 NM_001321150	NM_011680
RefSeq (protein)	NP_001308079 NP_003358 NP_997174	NP_035810
Location (UCSC)	Chr 19: 35.27 – 35.28 Mb	Chr 7: 30.95 – 30.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

USF2 has been shown to interact with USF1 (human gene),[7][8] PPRC1[9] and BRCA1.[10]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.[11]

References

1. GRCh38: Ensembl release 89: ENSG00000105698 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058239 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Groenen PM, Garcia E, Debeer P, Devriendt K, Fryns JP, Van de Ven WJ (Dec 1996). "Structure, sequence, and chromosome 19 localization of human USF2 and its rearrangement in a patient with multicystic renal dysplasia". Genomics. 38 (2): 141–8. doi:10.1006/geno.1996.0609. PMID 8954795.
6. "Entrez Gene: USF2 upstream transcription factor 2, c-fos interacting".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
8. Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
9. Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
10. Cable PL, Wilson CA, Calzone FJ, Rauscher FJ, Scully R, Livingston DM, Li L, Blackwell CB, Futreal PA, Afshari CA (Oct 2003). "Novel consensus DNA-binding sequence for BRCA1 protein complexes". Molecular Carcinogenesis. 38 (2): 85–96. doi:10.1002/mc.10148. PMID 14502648. S2CID 24956554.
11. Agirre X, Jiménez-Velasco A, San José-Enériz E, Garate L, Bandrés E, Cordeu L, Aparicio O, Saez B, Navarro G, Vilas-Zornoza A, Pérez-Roger I, García-Foncillas J, Torres A, Heiniger A, Calasanz MJ, Fortes P, Román-Gómez J, Prósper F (Dec 2008). "Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth". Molecular Cancer Research. 6 (12): 1830–40. doi:10.1158/1541-7786.MCR-08-0167. PMID 19074828.

Further reading

• Corre S, Galibert MD (Jan 2006). "[USF as a key regulatory element of gene expression]" (PDF). Médecine/Sciences. 22 (1): 62–7. doi:10.1051/medsci/200622162. PMID 16386222.
• Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M (1993). "Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers". Gene Expression. 2 (3): 231–40. PMC 6057381. PMID 1450663.
• Blanar MA, Rutter WJ (May 1992). "Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos". Science. 256 (5059): 1014–8. Bibcode:1992Sci...256.1014B. doi:10.1126/science.1589769. PMID 1589769.
• Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Ghosh AK, Datta PK, Jacob ST (Feb 1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
• Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
• Breen GA, Jordan EM (Apr 1997). "Regulation of the nuclear gene that encodes the alpha-subunit of the mitochondrial F0F1-ATP synthase complex. Activation by upstream stimulatory factor 2". The Journal of Biological Chemistry. 272 (16): 10538–42. doi:10.1074/jbc.272.16.10538. PMID 9099698.
• Nechushtan H, Zhang Z, Razin E (Apr 1997). "Microphthalmia (mi) in murine mast cells: regulation of its stimuli-mediated expression on the translational level". Blood. 89 (8): 2999–3008. doi:10.1182/blood.V89.8.2999. PMID 9108421.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Breen GA, Jordan EM (Aug 1999). "Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300". Biochimica et Biophysica Acta. 1428 (2–3): 169–76. doi:10.1016/s0304-4165(99)00061-6. PMID 10434034.
• Kumari D, Usdin K (Feb 2001). "Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome". The Journal of Biological Chemistry. 276 (6): 4357–64. doi:10.1074/jbc.M009629200. PMID 11058604.
• Kolonics A, Apáti A, Nahajevszky S, Gáti R, Brózik A, Magócsi M (2002). "Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia". Haematologia. 31 (2): 125–38. doi:10.1163/15685590152492936. PMID 11583024.
• Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (Jul 2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". The Biochemical Journal. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMC 1222691. PMID 11945176.
• Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM (Apr 2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis. 32 (4): 247–58. doi:10.1002/gene.10078. PMID 11948912. S2CID 12132097.
• Moore ML, Park EA, McMillin JB (May 2003). "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". The Journal of Biological Chemistry. 278 (19): 17263–8. doi:10.1074/jbc.M210486200. PMID 12611894.
• Pickwell GV, Shih H, Quattrochi LC (Apr 2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochemical Pharmacology. 65 (7): 1087–96. doi:10.1016/S0006-2952(03)00037-6. PMID 12663044.
• Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood. 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.

External links

• FactorBook USF2