UNC45A

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.[5][6]

UNC45A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DBA
Identifiers
Aliases	UNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A
External IDs	OMIM: 611219 MGI: 2142246 HomoloGene: 32423 GeneCards: UNC45A
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,930,180 bp[1] End 90,954,093 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2 Start 80,325,292 bp[2] End 80,347,993 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Hsp90 protein binding • GO:0001948 protein binding • cadherin binding Cellular component • cytoplasm • perinuclear region of cytoplasm • cell nucleus • Golgi apparatus • cytosol • nuclear speck Biological process • multicellular organism development • cell differentiation • muscle organ development • chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55898	101869
Ensembl	ENSG00000140553	ENSMUSG00000030533
UniProt	Q9H3U1	Q99KD5
RefSeq (mRNA)	NM_001039675 NM_017979 NM_018671 NM_001323619 NM_001323620 NM_001323621	NM_133952
RefSeq (protein)	NP_001034764 NP_001310548 NP_001310549 NP_001310550 NP_061141	NP_598713
Location (UCSC)	Chr 15: 90.93 – 90.95 Mb	Chr 7: 80.33 – 80.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000140553 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030533 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID 12356907.
6. "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

• Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC 2043524. PMID 17872978.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC 1430258. PMID 16478993.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.